Genome Mining Reveals High Topological Diversity of ω-Ester Containing Peptides and Divergent Evolution of ATP-Grasp Macrocyclases.
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DOI: 10.1021/jacs.9b12076
Abstract: ω-Ester containing peptides (OEPs) are a family of ribosomally synthesized and post-translationally modified peptides (RiPPs) containing intramolecular ω-ester or ω-amide bonds. Although their distinct side-to-side connections may create considerable topological diversity of multicyclic peptides, it… read more here.
Keywords: atp grasp; ester; containing peptides; genome mining ... See more keywords
Reconstitution of polythioamide antibiotic backbone formation reveals unusual thiotemplated assembly strategy
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1918759117
Abstract: Significance Nonribosomal peptides (NRPs) are a vast class of natural products and an important source of therapeutics. Typically, these secondary metabolites are assembled by NRP synthetases (NRPSs) that function on substrates covalently linked to the… read more here.
Keywords: unusual thiotemplated; atp grasp; secondary metabolites; nrps independent ... See more keywords