Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor formation
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.01.036
Abstract: Background Fast growing cancer cells require greater amounts of ATP than normal cells. Although glycolysis was suggested as a source of anabolic metabolism based on lactate production, the main source of ATP to support cancer… read more here.
Keywords: slc25a11; nsclc melanoma; cancer cells; atp production ... See more keywords
Lactate-Mediated Protection of Retinal Ganglion Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.03.005
Abstract: Loss of retinal ganglion cells (RGCs) is a leading cause of blinding conditions. The purpose of this study was to evaluate the effect of extracellular l-lactate on RGC survival facilitated through lactate metabolism and ATP… read more here.
Keywords: retinal ganglion; lactate; ganglion cells; rgc survival ... See more keywords
Respiratory ATP cost and benefit of arbuscular mycorrhizal symbiosis with Nicotiana tabacum at different growth stages and under salinity.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of plant physiology"
DOI: 10.1016/j.jplph.2017.08.012
Abstract: Growth and maintenance partly depend on both respiration and ATP production during oxidative phosphorylation in leaves. Under stress, ATP is needed to maintain the accumulated biomass. ATP production mostly proceeds from the cytochrome oxidase pathway… read more here.
Keywords: atp; arbuscular mycorrhizal; different growth; atp production ... See more keywords
Urocortin stimulates ERK1/2 phosphorylation and proliferation but reduces ATP production of MCF7 breast cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2022.111610
Abstract: Urocortins are members of the stress-related corticotropin-releasing factor family. Small amounts of them are present in the circulation and they are produced locally in various tissues of higher vertebrates. Aside from regulating circulation, or food… read more here.
Keywords: breast cancer; cancer cells; atp production; proliferation ... See more keywords
Decreased ATP production and myocardial contractile reserve in metabolic heart disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2018.01.017
Abstract: Metabolic syndrome is a cluster of obesity-related metabolic abnormalities that lead to metabolic heart disease (MHD) with left ventricular pump dysfunction. Although MHD is thought to be associated with myocardial energetic deficiency, two key questions… read more here.
Keywords: hfhs hearts; heart; atp production;
Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly.
Sign Up to like & getrecommendations! Published in 2021 at "Nature cell biology"
DOI: 10.1038/s41556-021-00760-4
Abstract: Cells respond to stress by blocking translation, rewiring metabolism and forming transient messenger ribonucleoprotein assemblies called stress granules (SGs). After stress release, re-establishing homeostasis and disassembling SGs requires ATP-consuming processes. However, the molecular mechanisms whereby… read more here.
Keywords: metabolism; atp production; stress; amyloids pyruvate ... See more keywords
Glutamine and serum starvation alters the ATP production, oxidative stress, and abundance of mitochondrial RNAs in extracellular vesicles produced by cancer cells
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-73943-2
Abstract: Induction of autophagy represents an effective survival strategy for nutrient-deprived or stressed cancer cells. Autophagy contributes to the modulation of communication within the tumor microenvironment. Here, we conducted a study of the metabolic and signaling… read more here.
Keywords: cancer; cancer cells; serum starvation; atp production ... See more keywords
Berberine chloride (dual topoisomerase I and II inhibitor) modulate mitochondrial uncoupling protein (UCP1) in molecular docking and dynamic with in-vitro cytotoxic and mitochondrial ATP production
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2021.2024255
Abstract: Abstract Obesity initiates numerous diseases like cardiovascular, metabolic, and type 2 diabetes, and obesity is a vital cause of death worldwide. Plants are necessary to the source of life. Several drug compounds isolated from plants… read more here.
Keywords: berberine chloride; mitochondrial uncoupling; berberine; chloride dual ... See more keywords
Mitochondrial fatty acid oxidation is the major source of cardiac ATP production in heart failure with preserved ejection fraction.
Sign Up to like & getrecommendations! Published in 2024 at "Cardiovascular research"
DOI: 10.1093/cvr/cvae006
Abstract: AIMS Heart failure with preserved ejection fraction (HFpEF) is a prevalent disease worldwide. While it is well established that alterations of cardiac energy metabolism contribute to cardiovascular pathology, the precise source of fuel used by… read more here.
Keywords: acid oxidation; heart; atp production; oxidation ... See more keywords
Aerobic scope falls to nil at Pcrit and anaerobic ATP production increases below Pcrit in the tidepool sculpin, Oligocottus maculosus
Sign Up to like & getrecommendations! Published in 2022 at "Biology Letters"
DOI: 10.1098/rsbl.2022.0342
Abstract: The critical oxygen tension of whole-animal oxygen uptake rate, or Pcrit, has historically been defined as the oxygen partial pressure (PO2) at which aerobic scope falls to zero and further declines in PO2 require substrate-level… read more here.
Keywords: scope falls; aerobic scope; scope; atp production ... See more keywords
H2O2‐induced oxidative stress disrupts mitochondrial functions and impairs migratory potential of human epidermal melanocytes
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Dermatology"
DOI: 10.1111/exd.14134
Abstract: Reactive oxygen species (ROS) have already been demonstrated to impede the migratory ability in non‐melanocytic cell lines by depleting mitochondrial ATP production. Therefore, understanding the mitochondrial metabolic response to migration in the presence of ROS… read more here.
Keywords: migratory potential; atp; migration; atp production ... See more keywords