Synergistic Binding of ATP and Nucleic Acids Necessitates UPF1's ATPase Functional Cycle.
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DOI: 10.1021/acs.jcim.3c00247
Abstract: UPF1 is a core protein in the nonsense mRNA degradation (NMD) surveillance pathway that degrades aberrant mRNA. UPF1 has both ATPase and RNA helicase activities, but it exhibits mutually exclusive binding of ATP and RNA.… read more here.
Keywords: state; upf1 atpase; atp rna; atp ... See more keywords