A molecular explanation of cardiovascular protection through abnormal cannabidiol: Involving the dysfunctional β‐adrenergic and ATP‐sensitive K+ channel activity in cardiovascular compromised preterm infants
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22849
Abstract: Growing cannabis efficacy, usage frequency, legal supply, and declining awareness of danger recently led to expanded United States cannabis exposure. In turn, cannabis use among elderly people over 50 has more than tripled in a… read more here.
Keywords: abnormal cannabidiol; atp sensitive; sensitive channel; preterm infants ... See more keywords
Psychotropic Effects of a New Pyrazolo[C]Pyridine Derivate GIZh-72 are Related to Functional Activity of Atp-Sensitive Potassium Channels
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-020-04729-5
Abstract: We studied the influence of intraperitoneal injection of ATP-sensitive potassium channels inhibitor glibenclamide in doses of 0.01, 0.1, 1, and 10 mg/kg on the effects of a new pyrazolo[C]pyridine derivative GIZh-72 (4,6-dimethyl-2-(4-chlorphenyl)-2,3-dihydro-1Hpyrazolo[ 4,3-C]pyridine-3-on, chloral hydrate;… read more here.
Keywords: potassium channels; sensitive potassium; effects new; atp sensitive ... See more keywords
A novel carbazole-based hydrogen-sulfide donor suppresses seizures and upregulates ATP-sensitive potassium channels
Sign Up to like & getrecommendations! Published in 2020 at "Applied Materials Today"
DOI: 10.1016/j.apmt.2020.100559
Abstract: Abstract Epilepsy is characterized by repeated spontaneous seizures and remains untreatable due to its complicate pathogenesis. Low-dose hydrogen sulfide (H2S) has been shown to exert antiepileptic and protective effects in the central nervous system, but… read more here.
Keywords: sensitive potassium; h2s donor; carbazole based; atp sensitive ... See more keywords
Existence of ATP sensitive potassium currents on human periodontal ligament cells.
Sign Up to like & getrecommendations! Published in 2017 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2017.01.006
Abstract: OBJECTIVE Potassium channels of the ATP-sensitive family (KATP channel) are inhibited by increase in intracellular ATP. Electrophysiological studies have demonstrated that the kinetics and pharmacological properties of KATP channels vary among different tissues, suggesting structurally… read more here.
Keywords: periodontal ligament; atp sensitive; human pdl; channel ... See more keywords
Therapeutic potential of ATP-sensitive potassium channels in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2021.01.003
Abstract: In the past decade, there was an increasing interest in the therapeutic potential targeting ATP-sensitive potassium (KATP) channels for an effective treatment of Parkinson's disease (PD). KATP channels are widely expressed in the central nervous… read more here.
Keywords: sensitive potassium; katp channels; atp sensitive; parkinson disease ... See more keywords
Mechanistic Pathways of ATP Sensitive Potassium Channels Referring to Cardio-Protective Effects and Cellular Functions.
Sign Up to like & getrecommendations! Published in 2019 at "Drug research"
DOI: 10.1055/a-0806-7207
Abstract: A study of potassium channels correlates the fundamentals of mechanistic pathways and various physiological functions. The knowledge of these pathways provides the background, how to determine unit cell functions and to affect cardio protection. ATP… read more here.
Keywords: potassium channels; potassium; sensitive potassium; atp sensitive ... See more keywords
Exploring the role of ATP-sensitive potassium channel, eNOS, and P-glycoprotein in mediating the hepatoprotective activity of nicorandil in methotrexate-induced liver injury in rats.
Sign Up to like & getrecommendations! Published in 2023 at "Immunopharmacology and immunotoxicology"
DOI: 10.1080/08923973.2023.2201659
Abstract: BACKGROUND Methotrexate (MTX) is a commonly used chemotherapeutic agent; however, its clinical use is challenged by various types of injuries, including hepatotoxic side effects. Therefore, finding new protective drugs against MTX-induced toxicities is a critical… read more here.
Keywords: enos glycoprotein; liver injury; atp sensitive; potassium channel ... See more keywords
Trapping endoplasmic reticulum with amphiphilic AIE-active sensor via specific interaction of ATP-sensitive potassium (KATP)
Sign Up to like & getrecommendations! Published in 2021 at "National Science Review"
DOI: 10.1093/nsr/nwaa198
Abstract: Abstract The current aggregation-induced emission luminogens (AIEgens) sometimes suffer from poor targeting selectivity due to undesirable aggregation in the hydrophilic biosystem with ‘always-on’ fluorescence or unspecific aggregation in the lipophilic organelle with prematurely activated fluorescence.… read more here.
Keywords: aggregation; sensitive potassium; endoplasmic reticulum; potassium katp ... See more keywords
Differential actions of AMP kinase on ATP‐sensitive K+ currents in ventral tegmental area and substantia nigra zona compacta neurons
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.13756
Abstract: ATP‐sensitive K+ (K‐ATP) channels play significant roles in regulating the excitability of dopamine neurons in the substantia nigra zona compacta (SNC). We showed previously that K‐ATP channel function is up‐regulated by AMP‐activated protein kinase (AMPK).… read more here.
Keywords: vta; atp sensitive; nigra zona; ventral tegmental ... See more keywords
Extracranial activation of ATP-sensitive potassium channels induces vasodilation without nociceptive effects
Sign Up to like & getrecommendations! Published in 2019 at "Cephalalgia"
DOI: 10.1177/0333102419888490
Abstract: Introduction Levcromakalim opens ATP-sensitive potassium channels (KATP channel) and induces head pain in healthy volunteers and migraine headache in migraine patients, but no pain in other parts of the body. KATP channels are expressed in… read more here.
Keywords: potassium channels; sensitive potassium; placebo forehead; atp sensitive ... See more keywords
PLCβ-Mediated Depletion of PIP2 and ATP-Sensitive K+ Channels Are Involved in Arginine Vasopressin-Induced Facilitation of Neuronal Excitability and LTP in the Dentate Gyrus
Sign Up to like & getrecommendations! Published in 2022 at "eNeuro"
DOI: 10.1523/eneuro.0120-22.2022
Abstract: Abstract Arginine vasopressin (AVP) serves as a neuromodulator in the brain. The hippocampus is one of the major targets for AVP, as it has been demonstrated that the hippocampus receives vasopressinergic innervation and expresses AVP… read more here.
Keywords: sensitive channels; arginine vasopressin; plc; atp sensitive ... See more keywords