Perfusion cultures require optimum respiratory ATP supply to maximize cell‐specific and volumetric productivities
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26926
Abstract: Perfusion processes are an emerging alternative to common fed‐batch processes in the growing biopharmaceutical industry. However, the challenge of maintaining high cell‐specific productivities remains. In this study, glucose limitation was applied to two perfusion steady… read more here.
Keywords: cell specific; respiratory atp; atp supply; perfusion ... See more keywords
The self-assembled α-lactalbumin-oleic acid complex inhibits ATP supply from both glycolysis and the TCA cycle in HepG2 cells and HepG2-bearing nude mice.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.05.030
Abstract: Energy metabolism has been a predominant target for anti-cancer drug development. The self-assembled anti-tumor α-lactalbumin-oleic acid complex (α-LA-OA) affects the energy metabolism of tumor cells, however, the role of targeting energy metabolism in its anti-tumor… read more here.
Keywords: glycolysis; self assembled; energy metabolism; atp supply ... See more keywords
MFN2 mediates ER-mitochondrial coupling during ER stress through specialized stable contact sites
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.918691
Abstract: Endoplasmic reticulum (ER) functions critically depend on a suitable ATP supply to fuel ER chaperons and protein trafficking. A disruption of the ability of the ER to traffic and fold proteins leads to ER stress… read more here.
Keywords: stress; atp supply; mitochondrial coupling; mfn2 mediates ... See more keywords