F‐ATP synthase and the permeability transition pore: fewer doubts, more certainties
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13485
Abstract: Whether the mitochondrial permeability transition pore (PTP), also called mitochondrial megachannel (MMC), originates from the F‐ATP synthase is a matter of controversy. This hypothesis is supported both by site‐directed mutagenesis of specific residues of F‐ATP… read more here.
Keywords: permeability transition; atp synthase; transition pore;
Engineering protein fragments via evolutionary and protein–protein interaction algorithms: de novo design of peptide inhibitors for FOF1‐ATP synthase
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13988
Abstract: Enzyme subunit interfaces have remarkable potential in drug design as both target and scaffold for their own inhibitors. We show an evolution‐driven strategy for the de novo design of peptide inhibitors targeting interfaces of the… read more here.
Keywords: protein; atp synthase; peptide; novo design ... See more keywords
Halting ionic shuttle to disrupt the synthetic machinery—Structural and molecular insights into the inhibitory roles of Bedaquiline towards Mycobacterium tuberculosis ATP synthase in the treatment of tuberculosis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28891
Abstract: Therapeutic targeting of the adenosine triphosphate (ATP) machinery of Mycobacterium tuberculosis (Mtb) has recently presented a potent and alternative measure to halt the pathogenesis of tuberculosis. This has been potentiated by the development of bedaquiline… read more here.
Keywords: atp synthase; molecule; machinery; bdq ... See more keywords
Beneficial effect of polyphenols in COVID‐19 and the ectopic F1FO‐ATP synthase: Is there a link?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30306
Abstract: COVID‐19 has been proposed to be an endothelial disease, as endothelial damage and oxidative stress contribute to its systemic inflammatory and thrombotic events. Polyphenols, natural antioxidant compounds appear as promising agents to prevent and treat… read more here.
Keywords: atp synthase; polyphenols covid; ectopic f1fo; f1fo atp ... See more keywords
Purification and Reconstitution of Ilyobacter tartaricus ATP Synthase.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8556-2_3
Abstract: F-type adenosine triphosphate (ATP) synthase is a membrane-bound macromolecular complex, which is responsible for the synthesis of ATP, the universal energy source in living cells. This enzyme uses the proton- or sodium-motive force to power… read more here.
Keywords: atp synthase; ilyobacter tartaricus; tartaricus atp; synthase ... See more keywords
ATP Synthase: Expression, Purification, and Function.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9869-2_5
Abstract: ATP synthase is an essential enzyme found in all known forms of life, generating the majority of cellular energy via a rotary catalytic mechanism. Here, we describe the in-depth methods for expression, purification, and functional… read more here.
Keywords: purification function; atp synthase; expression purification; synthase expression ... See more keywords
Phylogenetic Profiling of Mitochondrial Proteins and Integration Analysis of Bacterial Transcription Units Suggest Evolution of F1Fo ATP Synthase from Multiple Modules
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Evolution"
DOI: 10.1007/s00239-017-9819-3
Abstract: ATP synthase is a complex universal enzyme responsible for ATP synthesis across all kingdoms of life. The F-type ATP synthase has been suggested to have evolved from two functionally independent, catalytic (F1) and membrane bound… read more here.
Keywords: atp synthase; evolution; synthase; transcription units ... See more keywords
ATP Synthase Subunit Beta Immunostaining is Reduced in the Sclerotic Hippocampus of Epilepsy Patients
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-018-0641-2
Abstract: Epilepsy is a common disease presenting with recurrent seizures. Hippocampal sclerosis (HS) is the commonest histopathological alteration in patients with temporal lobe epilepsy (TLE) undergoing surgery. HS physiopathogenesis is debatable. We have recently studied, by… read more here.
Keywords: epilepsy; atp synthase; beta immunostaining; subunit beta ... See more keywords
Current understanding of structure, function and biogenesis of yeast mitochondrial ATP synthase
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-019-09809-4
Abstract: The yeast mitochondrial ATP synthase is a rotary molecular machine primarily responsible for the production of energy used to drive cellular processes. The enzyme complex is composed of 17 different subunits grouped into a soluble… read more here.
Keywords: atp synthase; synthase; mitochondrial atp; yeast mitochondrial ... See more keywords
Cloning and different expression of ATP synthase genes between propargite resistant and susceptible strains of Tetranychus cinnabarinus (Acarina: Tetranychidae)
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Asia-pacific Entomology"
DOI: 10.1016/j.aspen.2018.01.023
Abstract: Abstract The carmine spider mite, Tetranychus cinnabarinus (Boisduval), is a serious phytophagous mite damaging important crops and can rapidly develop resistance to acaricides. Mitochondrial ATP synthase (F1F0 ATP synthase) is an important target site of… read more here.
Keywords: atp synthase; synthase genes; expression; resistant susceptible ... See more keywords
Mutation Q259L in subunit beta in Bacillus subtilis ATP synthase attenuates ADP-inhibition and decreases fitness in mixed cultures.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.12.075
Abstract: The ATPase activity of H+-FOF1-ATP synthase (FOF1) is down-regulated by several mechanisms. The most universal of them found in bacterial, chloroplast and mitochondrial enzymes is non-competitive inhibition by MgADP (ADP-inhibition). When MgADP binds in a… read more here.
Keywords: atp synthase; adp inhibition; inhibition; bacillus ... See more keywords