Bacterial F-type ATP synthases follow a well-choreographed assembly pathway
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28828-1
Abstract: F-type ATP synthases are multiprotein complexes composed of two separate coupled motors (F 1 and F O ) generating adenosine triphosphate (ATP) as the universal major energy source in a variety of relevant biological processes… read more here.
Keywords: assembly pathway; bacterial type; type atp; atp synthases ... See more keywords
Unusual features of the c-ring of F1FO ATP synthases
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55092-z
Abstract: Membrane integral ATP synthases produce adenosine triphosphate, the universal “energy currency” of most organisms. However, important details of proton driven energy conversion are still unknown. We present the first high-resolution structure (2.3 Å) of the in… read more here.
Keywords: unusual features; ring f1fo; f1fo atp; atp synthases ... See more keywords
Bedaquiline inhibits the yeast and human mitochondrial ATP synthases
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-01173-z
Abstract: Bedaquiline (BDQ, Sirturo) has been approved to treat multidrug resistant forms of Mycobacterium tuberculosis. Prior studies suggested that BDQ was a selective inhibitor of the ATP synthase from M. tuberculosis. However, Sirturo treatment leads to… read more here.
Keywords: human mitochondrial; mitochondrial atp; bdq; atp synthases ... See more keywords
Insights into the regulatory function of the ɛ subunit from bacterial F-type ATP synthases: a comparison of structural, biochemical and biophysical data
Sign Up to like & getrecommendations! Published in 2018 at "Open Biology"
DOI: 10.1098/rsob.170275
Abstract: ATP synthases catalyse the formation of ATP, the most common chemical energy storage unit found in living cells. These enzymes are driven by an electrochemical ion gradient, which allows the catalytic evolution of ATP by… read more here.
Keywords: atp; atp hydrolysis; biochemical biophysical; atp synthases ... See more keywords
Expression of the Cyanobacterial FoF1 ATP Synthase Regulator AtpΘ Depends on Small DNA-Binding Proteins and Differential mRNA Stability
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02562-21
Abstract: FoF1 ATP synthases produce ATP, the universal biological energy source. Under unfavorable conditions, ATP synthases can operate in a futile reverse reaction, pumping protons while ATP is used up. ABSTRACT FoF1 ATP synthases produce ATP,… read more here.
Keywords: fof1 atp; atpt; atp synthase; atp synthases ... See more keywords
Thermodynamic performance of coupled enzymatic reactions: A chemical kinetics model for analyzing cotransporters, ion pumps, and ATP synthases.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical chemistry"
DOI: 10.2139/ssrn.4229442
Abstract: Previous research has suggested that molecular energy converters such as ATP synthases, ion pumps, and cotransporters operate via spatially separate pathways for free energy donor and acceptor reactions linked by a protein molecule. We present… read more here.
Keywords: ion pumps; atp synthases; model; chemical kinetics ... See more keywords
CryoEM Reveals the Complexity and Diversity of ATP Synthases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.864006
Abstract: During respiration, adenosine triphosphate (ATP) synthases harness the electrochemical proton motive force (PMF) generated by the electron transport chain (ETC) to synthesize ATP. These macromolecular machines operate by a remarkable rotary catalytic mechanism that couples… read more here.
Keywords: complexity diversity; cryoem reveals; atp synthases; diversity atp ... See more keywords
Modulation of the H+/ATP coupling ratio by ADP and ATP as a possible regulatory feature in the F-type ATP synthases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.1023031
Abstract: F-type ATP synthases are transmembrane enzymes, which play a central role in the metabolism of all aerobic and photosynthetic cells and organisms, being the major source of their ATP synthesis. Catalysis occurs via a rotary… read more here.
Keywords: atp synthases; atp coupling; type atp; coupling ratio ... See more keywords