ATPase Domain AFG3L2 Mutations Alter OPA1 Processing and Cause Optic Neuropathy
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Neurology"
DOI: 10.1002/ana.25723
Abstract: Dominant optic atrophy (DOA) is the most common inherited optic neuropathy, with a prevalence of 1:12,000 to 1:25,000. OPA1 mutations are found in 70% of DOA patients, with a significant number remaining undiagnosed. read more here.
Keywords: afg3l2 mutations; alter opa1; optic neuropathy; mutations alter ... See more keywords
Post-translational modifications in DNA topoisomerase 2α highlight the role of a eukaryote-specific residue in the ATPase domain
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27606-8
Abstract: Type 2 DNA topoisomerases (Top2) are critical components of key protein complexes involved in DNA replication, chromosome condensation and segregation, as well as gene transcription. The Top2 were found to be the main targets of… read more here.
Keywords: post translational; residue atpase; translational modifications; domain ... See more keywords
Molecular dynamics simulations of sulfone derivatives in complex with DNA topoisomerase IIα ATPase domain
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1831961
Abstract: Abstract Human topoisomerase II alpha (TopoIIα) is a crucial enzyme involved in maintaining genomic integrity during the process of DNA replication and mitotic division. It is a vital therapeutic target for designing novel anticancer agents… read more here.
Keywords: dna; dynamics simulations; atpase domain; molecular dynamics ... See more keywords
Alternative ATPase domain interactions in eukaryotic Hsp70 chaperones
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1155784
Abstract: Hsp70 molecular chaperones are essential components for maintaining protein homeostasis within cells. They interact with substrate or client proteins in a well characterised fashion that is regulated by ATP and supported by co-chaperones. In eukaryotes… read more here.
Keywords: alternative atpase; atpase domain; domain interactions; atpase ... See more keywords