Inhibition of post-termination ribosome recycling at premature termination codons in UPF1 ATPase mutants
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DOI: 10.7554/elife.57834
Abstract: Recognition and rapid degradation of mRNA harboring premature translation termination codons (PTCs) serves to protect cells from accumulating non-functional and potentially toxic truncated polypeptides. Targeting of PTC-containing transcripts is mediated by the nonsense-mediated mRNA decay… read more here.
Keywords: atpase; termination codons; upf1 atpase; atpase mutants ... See more keywords