Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split‐washer‐type mechanism for substrate unfolding
Sign Up to like & getrecommendations! Published in 2019 at "Febs Letters"
DOI: 10.1002/1873-3468.13667
Abstract: Several pathologies have been associated with the AAA+ ATPase p97, an enzyme essential to protein homeostasis. Heterozygous polymorphisms in p97 have been shown to cause neurological disease, while elevated proteotoxic stress in tumours has made… read more here.
Keywords: mechanism; atpase p97; p97; aaa atpase ... See more keywords
The AAA+ ATPase p97 as a novel parasite and tuberculosis drug target.
Sign Up to like & getrecommendations! Published in 2022 at "Trends in parasitology"
DOI: 10.1016/j.pt.2022.03.004
Abstract: The multifunctional AAA+ ATPase p97 is an unfoldase/segregase involved in various cellular processes and present in all kingdoms of life. In mammals and yeast, p97 functions upstream of the proteasome. Interestingly, proteasome inhibitors targeting pathogenic… read more here.
Keywords: aaa atpase; drug; atpase p97; drug target ... See more keywords
Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208941120
Abstract: Significance Chaperones are key players in cellular homeostasis that can prevent potentially toxic protein misfolding and aggregation and allow stalled processes to resolve and continue. One of them is a AAA+ ATPase, p97, that acts… read more here.
Keywords: atpase p97; p97; adaptor; aaa atpase ... See more keywords