APE1 assembles biomolecular condensates to promote the ATR–Chk1 DNA damage response in nucleolus
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DOI: 10.1101/2022.08.22.504787
Abstract: Multifunctional protein APE1/APEX1/HAP1/Ref-1 (designated as APE1) plays important roles in nuclease-mediated DNA repair and redox regulation in transcription. However, it is unclear how APE1 regulates the DNA damage response (DDR) pathways and influences genome integrity… read more here.
Keywords: ape1; dna damage; atr ddr; ddr ... See more keywords