APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition.
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DOI: 10.1158/0008-5472.can-16-3389
Abstract: The apolipoprotein B mRNA editing enzyme catalytic polypeptide-like APOBEC3A and APOBEC3B have emerged as key mutation drivers in cancer. Here, we show that APOBEC3A and APOBEC3B activities impose a unique type of replication stress by… read more here.
Keywords: apobec3a apobec3b; apobec3b activities; atr inhibition; cancer ... See more keywords
Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes.
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DOI: 10.1158/0008-5472.can-17-3970
Abstract: Heterozygous somatic mutations in spliceosome genes (U2AF1, SF3B1, ZRSR2, or SRSF2) occur in >50% of patients with myelodysplastic syndrome (MDS). These mutations occur early in disease development, suggesting that they contribute to MDS pathogenesis and… read more here.
Keywords: loop associated; atr; dna; u2af1 s34f ... See more keywords
Abstract 1620: ATR inhibition for the treatment of ATM-deficient gastric cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1620
Abstract: ATM and ATR are central kinases in the cellular response to DNA damage and play a crucial role in maintaining genome integrity. Inactivation of ATM has been observed in multiple tumor types and pre-clinical studies… read more here.
Keywords: gastric cancer; atr inhibition; inhibition; cancer ... See more keywords
ATR Inhibition as an Attractive Therapeutic Resource against Cancer.
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DOI: 10.1158/2159-8290.cd-20-1354
Abstract: In this issue of Cancer Discovery, Yap and colleagues demonstrate in a phase I trial enrolling 22 patients diagnosed with advanced solid tumors that BAY 1895344, a new potent and specific ATR inhibitor, is safe… read more here.
Keywords: inhibition attractive; atr inhibition; resource cancer; cancer ... See more keywords
Therapeutic Vulnerability to ATR Inhibition in Concurrent NF1 and ATRX-Deficient/ALT-Positive High-Grade Solid Tumors
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DOI: 10.3390/cancers14123015
Abstract: Simple Summary Tumors of the brain and nerves develop frequently in patients with neurofibromatosis type 1. Many are benign growths, such as pilocytic astrocytomas in the brain and neurofibromas in the nerves. However, in some… read more here.
Keywords: cell; cell line; deficient; atr inhibition ... See more keywords