The ATR-WEE1 kinase module inhibits the MAC complex to regulate replication stress response
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa1082
Abstract: Abstract DNA damage response is a fundamental mechanism to maintain genome stability. The ATR-WEE1 kinase module plays a central role in response to replication stress. Although the ATR-WEE1 pathway has been well studied in yeasts… read more here.
Keywords: mac complex; atr wee1; wee1; replication stress ... See more keywords
Abstract 2826: Differential activity of ATR and WEE1 inhibitors in DLBCL subtypes is linked to replication stress and differences in mode of action
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DOI: 10.1158/1538-7445.am2018-2826
Abstract: The checkpoint kinases ATR and WEE1 protect cells from replication stress (RS), a hallmark of cancer that has potential to be exploited for cancer treatment. ATR and WEE1 inhibitors are in early clinical trials. Here… read more here.
Keywords: cell lines; atr wee1; replication stress; day ... See more keywords