Inhalable poly(lactic‐co‐glycolic acid) (PLGA) microparticles encapsulating all‐trans‐Retinoic acid (ATRA) as a host‐directed, adjunctive treatment for Mycobacterium tuberculosis infection
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.10.020
Abstract: Graphical abstract Figure. No caption available. Abstract Ending the tuberculosis (TB) epidemic by 2030 was recently listed in the United Nations (UN) Sustainable Development Goals alongside HIV/AIDS and malaria as it continues to be a… read more here.
Keywords: trans retinoic; treatment; pathology; mycobacterium tuberculosis ... See more keywords
All‐trans retinoic acid (ATRA)‐induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL)
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DOI: 10.1111/ejh.13367
Abstract: In acute promyelocytic leukemia (APL), normal retinoid signaling is disrupted by an abnormal PML‐RARα fusion oncoprotein, leading to a block in cell differentiation. Therapeutic concentrations of all‐trans‐retinoic acid (ATRA) can restore retinoid‐induced transcription and promote… read more here.
Keywords: trans retinoic; acute promyelocytic; promyelocytic leukemia; differentiation ... See more keywords
ATRA Entrapped in DSPC Liposome Enhances Anti-metastasis Effect on Lung and Liver During B16F10 Cell Line Metastasis in C57BL6 Mice.
Sign Up to like & getrecommendations! Published in 2017 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520616666160927103458
Abstract: BACKGROUND The high mortality rate of lung cancer is highly associated with faster metastasis spread. All Trans Retinoic Acid (ATRA), being the first choice drug for leukemia therapy is now under intense study for its… read more here.
Keywords: cell line; b16f10; anti metastasis; metastasis ... See more keywords
Development of Inhalable ATRA-Loaded PLGA Nanoparticles as Host-Directed Immunotherapy against Tuberculosis
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DOI: 10.3390/pharmaceutics14081745
Abstract: Developing new effective treatment strategies to overcome the rise in multi-drug resistant tuberculosis cases (MDR-TB) represents a global challenge. A host-directed therapy (HDT), acting on the host immune response rather than Mtb directly, could address… read more here.
Keywords: host directed; tuberculosis; atra; inhalable atra ... See more keywords
Involvement of Notch2 in all-trans retinoic acid-induced inhibition of mouse embryonic palate mesenchymal cell proliferation
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DOI: 10.3892/mmr.2017.6940
Abstract: Cleft palate is among the most common congenital disorders, and can be induced by exposure to all-trans retinoic acid (atRA) during mice and human embryogenesis. However, the mechanism underlying the implication of atRA in the… read more here.
Keywords: induced inhibition; proliferation; palate; mouse ... See more keywords