Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA‐induced differentiation of leukemic cells
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DOI: 10.1002/1878-0261.12614
Abstract: Ubiquitin/ISG15‐conjugating enzyme E2L6 (UBE2L6) is a critical enzyme in ISGylation, a post‐translational protein modification that conjugates the ubiquitin‐like modifier, interferon‐stimulated gene 15 (ISG15), to target substrates. Previous gene expression studies in acute promyelocytic leukemia (APL)… read more here.
Keywords: atra induced; isgylation; apl cells; expression ... See more keywords
Proteomic Profiling of HL-60 Cells during ATRA-Induced Differentiation
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-018-4210-y
Abstract: Acute promyelocytic leukemia, a form of acute myeloid leukemia, is characterized by cell differentiation arrest at the promyelocyte stage. Current therapeutic options include administration of all trans-retinoic acid (ATRA), but this treatment produces many side… read more here.
Keywords: induced differentiation; atra induced; proteomic profiling; differentiation ... See more keywords
Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment of an ensemble of activated signaling molecules and augments ATRA-induced myeloid cell differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Oncotarget"
DOI: 10.18632/oncotarget.27508
Abstract: Although ATRA represents a successful differentiation therapy for APL, it is largely ineffective for non-APL AMLs. Hence combination therapies using an agent targeting ATRA-regulated molecules that drive cell differentiation/arrest are of interest. Using the HL-60… read more here.
Keywords: nuclear enrichment; atra induced; differentiation; cell ... See more keywords
Inhibition of CRL-NEDD8 pathway as a new approach to enhance ATRA-induced differentiation of acute promyelocytic leukemia cells
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Medical Sciences"
DOI: 10.7150/ijms.23782
Abstract: The cullin-RING ligase (CRL)-NEDD8 pathway maintains essential cellular processes, including cell cycle progression, apoptosis, autophagy, DNA repair, antigen processing and signal transduction. Growing evidence demonstrates that the alteration of the CRL-NEDD8 pathway in some cancers… read more here.
Keywords: atra induced; acute promyelocytic; promyelocytic leukemia; nedd8 pathway ... See more keywords