Acetyltransferase p300 regulates atrial fibroblast senescence and age‐related atrial fibrosis through p53/Smad3 axis
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13743
Abstract: Atrial fibrosis induced by aging is one of the main causes of atrial fibrillation (AF), but the potential molecular mechanism is not clear. Acetyltransferase p300 participates in the cellular senescence and fibrosis, which might be… read more here.
Keywords: atrial fibrosis; senescence; p53; p300 ... See more keywords
Sodium Tanshinone IIA Sulfonate Prevents Angiotensin II-Induced Differentiation of Human Atrial Fibroblasts into Myofibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/6712585
Abstract: Differentiation of atrial fibroblasts into myofibroblasts plays a critical role in atrial fibrosis. Sodium tanshinone IIA sulfonate (DS-201), a water-soluble derivative of tanshinone IIA, has been shown to have potent antifibrotic properties. However, the protective… read more here.
Keywords: induced differentiation; atrial fibroblasts; tanshinone iia; fibroblasts myofibroblasts ... See more keywords
FABP4 Enhances Lipidic and Fibrotic Cardiac Structural and Ca2+ Dynamic Changes
Sign Up to like & getrecommendations! Published in 2024 at "Circulation: Arrhythmia and Electrophysiology"
DOI: 10.1161/circep.123.012683
Abstract: BACKGROUND: Adipocyte FABP4 (fatty acid-binding protein 4) is augmented in the epicardial stroma of patients with long-standing persistent atrial fibrillation. Because this molecule is released mainly by adipocytes, our objective was to study its role… read more here.
Keywords: atrial cardiomyocytes; epicardial subcutaneous; atrial fibroblasts; stroma ... See more keywords
Regulation of Atrial Fibrosis by the Bone
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension"
DOI: 10.1161/hypertensionaha.118.11544
Abstract: MR (mineralocorticoid receptor) antagonists have been demonstrated to provide beneficial effects on preventing atrial fibrosis. However, the underlying cellular and molecular mechanisms remain unclear. We aim to determine the role of osteoblast MR in atrial… read more here.
Keywords: bgr transgenic; fibrosis; atrial fibrosis; atrial fibroblasts ... See more keywords
IL-11 promotes Ang II-induced autophagy inhibition and mitochondrial dysfunction in atrial fibroblasts
Sign Up to like & getrecommendations! Published in 2025 at "Open Life Sciences"
DOI: 10.1515/biol-2025-1063
Abstract: Abstract This study aimed to investigate potential targets for the pathogenesis of atrial fibrillation to facilitate the development of effective treatments. Atrial fibroblasts were isolated and stimulated with 1 μM angiotensin-II (Ang-II) for 24 h. To increase… read more here.
Keywords: mitochondrial dysfunction; ang induced; atrial fibroblasts; autophagy inhibition ... See more keywords
Ezh2 Inhibits Replicative Senescence of Atrial Fibroblasts Through Promotion of H3K27me3 in the Promoter Regions of CDKN2a and Timp4 Genes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s374951
Abstract: Background In most cell types, replicative senescence (RS) is supposed to be a principle causative factor for aging. Atrial fibrosis, pathologically characterized by proliferation of atrial fibroblasts (AFs) and excessive accumulation of extracellular matrix proteins,… read more here.
Keywords: ezh2 inhibits; promoter regions; replicative senescence; atrial fibroblasts ... See more keywords
Reactive oxygen species mediated oxidative stress links diabetes and atrial fibrillation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2018.8472
Abstract: Diabetes is an independent risk factor for atrial fibrillation (AF); however, the underlying mechanism linking diabetes and AF remains to be clarified. The present study aimed to explore the molecular mechanism of increased reactive oxygen… read more here.
Keywords: atrial fibrillation; reactive oxygen; atrial fibroblasts; oxygen species ... See more keywords