The crucial role of activin A/ALK4 pathway in the pathogenesis of Ang-II-induced atrial fibrosis and vulnerability to atrial fibrillation
Sign Up to like & getrecommendations! Published in 2017 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-017-0634-1
Abstract: AbstractsAtrial fibrosis, the hallmark of structural remodeling associated with atrial fibrillation (AF), is characterized by abnormal proliferation of atrial fibroblasts and excessive deposition of extracellular matrix. Transforming growth factor-β1 (TGF-β1)/activin receptor-like kinase 5 (ALK5)/Smad2/3/4 pathway… read more here.
Keywords: fibrosis; activin alk4; pathogenesis; atrial fibrosis ... See more keywords
Establishment of a lncRNA-miRNA-mRNA network in a rat model of atrial fibrosis by whole transcriptome sequencing
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Interventional Cardiac Electrophysiology"
DOI: 10.1007/s10840-022-01120-4
Abstract: Dysregulation of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) plays important roles in atrial fibrillation (AF). This study aimed to identify crucial lncRNAs, miRNAs, and mRNAs in AF based on whole transcriptome sequencing. Thirty Sprague… read more here.
Keywords: transcriptome sequencing; whole transcriptome; atrial fibrosis; model ... See more keywords
LncRNA NRON promotes M2 macrophage polarization and alleviates atrial fibrosis through suppressing exosomal miR-23a derived from atrial myocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Formosan Medical Association = Taiwan yi zhi"
DOI: 10.1016/j.jfma.2020.11.004
Abstract: BACKGROUND/PURPOSE miR-23a is a pro-hypertrophic miRNA that inhibits M2 macrophage polarization. A previous study demonstrated that lncRNA NRON alleviated atrial fibrosis through suppression of M1 macrophages activated by atrial myocytes. This study aimed to determine… read more here.
Keywords: atrial fibrosis; macrophage polarization; mir 23a; atrial myocytes ... See more keywords
Osteopontin induces atrial fibrosis by activating Akt/GSK-3β/β-catenin pathway and suppressing autophagy.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117328
Abstract: AIMS Atrial fibrosis is a common feature of atrial fibrillation (AF). Recently, it is reported that osteopontin (OPN) can induce fibrosis in lungs, livers and kidneys. However, its role in atrial fibrosis remains unclear. Here,… read more here.
Keywords: atrial fibrosis; gsk catenin; fibrosis; akt gsk ... See more keywords
LEFT ATRIAL FIBROSIS, FUNCTIONAL CHANGE, AND A RISK OF THROMBUS IN PATIENTS WITH ATRIAL FIBRILLATION: LEFT ATRIAL FIBROSIS BEGETS ATRIAL FIBRILLATION OR VICE VERSA?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(19)31128-3
Abstract: In patients with atrial fibrillation (AF), left atrial (LA) fibrosis is an important component of the arrhythmogenic substrate and is related to LA dysfunciton, which contribute the development of thromboembolism. However, there is little known… read more here.
Keywords: left atrial; atrial fibrillation; atrial fibrosis; patients atrial ... See more keywords
JK07 prevents atrial fibrosis and atrial fibrillation inducibility in a porcine DOCA model
Sign Up to like & getrecommendations! Published in 2023 at "Europace"
DOI: 10.1093/europace/euad122.065
Abstract: Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Geconcerteerde Onderzoeksactie (GOA) grant 499 of the University of Antwerp Industrieel OnderzoeksFonds/Strategisch Basisonderzoek 498 (IOF/SBO) research grant of the… read more here.
Keywords: atrial fibrosis; jk07; doca; doca veh ... See more keywords
Acetyltransferase p300 regulates atrial fibroblast senescence and age‐related atrial fibrosis through p53/Smad3 axis
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13743
Abstract: Atrial fibrosis induced by aging is one of the main causes of atrial fibrillation (AF), but the potential molecular mechanism is not clear. Acetyltransferase p300 participates in the cellular senescence and fibrosis, which might be… read more here.
Keywords: atrial fibrosis; senescence; p53; p300 ... See more keywords
Serum Lipopolysaccharide Is Associated with the Recurrence of Atrial Fibrillation after Radiofrequency Ablation by Increasing Systemic Inflammation and Atrial Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/2405972
Abstract: Objectives The gut microbiota and its metabolites are linked to inflammation and contribute to the progression of atrial fibrillation (AF), but the predictive value of the gut microbiota-derived metabolite lipopolysaccharide (LPS) for AF recurrence (RAF)… read more here.
Keywords: inflammation; atrial fibrosis; raf; atrial fibrillation ... See more keywords
LOXL2 Inhibitor Attenuates Angiotensin II-Induced Atrial Fibrosis and Vulnerability to Atrial Fibrillation through Inhibition of Transforming Growth Factor Beta-1 Smad2/3 Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Cerebrovascular diseases"
DOI: 10.1159/000518526
Abstract: OBJECTIVES Angiotensin II (Ang II)-induced atrial fibrosis plays a vital role in the development of atrial fibrillation (AF). Lysyl oxidase-like 2 (LOXL2) plays an essential role in matrix remodeling and fibrogenesis, indicating it may involve… read more here.
Keywords: ang induced; inhibitor; fibrosis; loxl2 ... See more keywords
Interleukin-11 Is Elevated in Patients with Atrial Fibrillation, Correlates with Serum Fibrosis Markers, and Represents a Therapeutic Target for Atrial Fibrosis.
Sign Up to like & getrecommendations! Published in 2023 at "Cerebrovascular diseases"
DOI: 10.1159/000527740
Abstract: INTRODUCTION Inflammatory cytokines are closely associated with developing cardiac fibrosis. This research aimed to explore the significant role of IL-11 in atrial fibrosis progression and potential therapeutic targets. METHODS 207 AF patients and 160 healthy… read more here.
Keywords: therapeutic target; atrial fibrosis; fibrosis markers; fibrosis ... See more keywords
Regulation of Atrial Fibrosis by the Bone
Sign Up to like & getrecommendations! Published in 2019 at "Hypertension"
DOI: 10.1161/hypertensionaha.118.11544
Abstract: MR (mineralocorticoid receptor) antagonists have been demonstrated to provide beneficial effects on preventing atrial fibrosis. However, the underlying cellular and molecular mechanisms remain unclear. We aim to determine the role of osteoblast MR in atrial… read more here.
Keywords: bgr transgenic; fibrosis; atrial fibrosis; atrial fibroblasts ... See more keywords