Diversity-Oriented Metal-Free Synthesis of Nitrogen-Containing Heterocycles Using Atropaldehyde Acetals as a Dual C3/C2-Synthon.
Sign Up to like & getrecommendations! Published in 2022 at "ChemSusChem"
DOI: 10.1002/cssc.202201301
Abstract: A highly efficient and elegant diversity-oriented reaction paradigm employing atropaldehyde acetals as a novel dual C2/C3 synthon was developed under metal-free conditions using glycine esters as the counter-part reagents, which allowed rapid synthesis of two… read more here.
Keywords: dual synthon; nitrogen containing; metal free; synthesis ... See more keywords
Acid-catalyzed cleavage of C-C bonds enables atropaldehyde acetals as masked C2 electrophiles for organic synthesis.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc04000f
Abstract: Acid-catalyzed tandem reactions of atropaldehyde acetals were established for the synthesis of three important molecules, 2,2-disubstituted indolin-3-ones, naphthofurans and stilbenes. The synthesis was realized using novel reaction cascades, which involved the same two initial steps:… read more here.
Keywords: atropaldehyde acetals; acid catalyzed; catalyzed cleavage; cleavage bonds ... See more keywords