Diagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Degeneration
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DOI: 10.1001/jamanetworkopen.2022.9588
Abstract: Key Points Question Can widely available atrophy measures on magnetic resonance imaging (MRI) increase diagnostic accuracy of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD)? Findings In this diagnostic study of 326 participants, different methods… read more here.
Keywords: magnetic resonance; resonance imaging; progressive supranuclear; atrophy ... See more keywords
Patterns of Regional Brain Atrophy and Brain Aging in Middle- and Older-Aged Adults With Type 1 Diabetes
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DOI: 10.1001/jamanetworkopen.2023.16182
Abstract: This cohort study evaluates neuroimaging markers of brain age and Alzheimer disease–like atrophy in participants with type 1 diabetes and assesses the association between cognition and brain aging indices. read more here.
Keywords: brain aging; regional brain; brain; patterns regional ... See more keywords
Association of Brain Atrophy With Disease Progression Independent of Relapse Activity in Patients With Relapsing Multiple Sclerosis.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.1025
Abstract: Importance The mechanisms driving neurodegeneration and brain atrophy in relapsing multiple sclerosis (RMS) are not completely understood. Objective To determine whether disability progression independent of relapse activity (PIRA) in patients with RMS is associated with… read more here.
Keywords: relapse activity; brain; atrophy; brain atrophy ... See more keywords
Reduced CYFIP2 Stability by Arg87 Variants Causing Human Neurological Disorders
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DOI: 10.1002/ana.25598
Abstract: We thank Dr Maeda et al for their careful review and for their contribution of an additional case related to our previous report, “Severe Brain Involvement in 5q Spinal Muscular Atrophy Type 0.” We would… read more here.
Keywords: stability arg87; presence; reduced cyfip2; cyfip2 stability ... See more keywords
Grey matter atrophy in patients with benign multiple sclerosis
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DOI: 10.1002/brb3.2679
Abstract: Brain atrophy appears during the progression of multiple sclerosis (MS) and is associated with the disability caused by the disease. read more here.
Keywords: matter atrophy; grey matter; atrophy patients; atrophy ... See more keywords
Longitudinal brain atrophy distribution in advanced Parkinson's disease: What makes the difference in “cognitive status” converters?
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DOI: 10.1002/hbm.24884
Abstract: We investigated the brain atrophy distribution pattern and rate of regional atrophy change in Parkinson's disease (PD) in association with the cognitive status to identify the morphological characteristics of conversion to mild cognitive impairment (MCI)… read more here.
Keywords: brain atrophy; cognitive status; disease; atrophy ... See more keywords
Identifying the regional substrates predictive of Alzheimer's disease progression through a convolutional neural network model and occlusion
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DOI: 10.1002/hbm.26026
Abstract: Progressive brain atrophy is a key neuropathological hallmark of Alzheimer's disease (AD) dementia. However, atrophy patterns along the progression of AD dementia are diffuse and variable and are often missed by univariate methods. Consequently, identifying… read more here.
Keywords: alzheimer disease; progression; atrophy; model ... See more keywords
Alterations of voxel‐wise spontaneous activity and corresponding brain functional networks in multiple system atrophy patients with mild cognitive impairment
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DOI: 10.1002/hbm.26058
Abstract: Emerging evidence has indicated that cognitive impairment is an underrecognized feature of multiple system atrophy (MSA). Mild cognitive impairment (MCI) is related to a high risk of dementia. However, the mechanism underlying MCI in MSA… read more here.
Keywords: msa; cognitive impairment; activity; atrophy ... See more keywords
Generative adversarial network constrained multiple loss autoencoder: A deep learning‐based individual atrophy detection for Alzheimer's disease and mild cognitive impairment
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DOI: 10.1002/hbm.26146
Abstract: Exploring individual brain atrophy patterns is of great value in precision medicine for Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, the current individual brain atrophy detection models are deficient. Here, we proposed a… read more here.
Keywords: individual atrophy; atrophy patterns; alzheimer disease; atrophy detection ... See more keywords
Visual impairment and retinal and brain neurodegeneration: A population‐based study
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DOI: 10.1002/hbm.26237
Abstract: Visual impairment and retinal neurodegeneration are intrinsically connected and both have been associated with cognitive impairment and brain atrophy, but the underlying mechanisms remain unclear. To investigate whether transneuronal degeneration is implicated, we systematically assessed… read more here.
Keywords: retinal neurodegeneration; brain; neurodegeneration; impairment retinal ... See more keywords
Cinnamaldehyde regulates H2O 2‐induced skeletal muscle atrophy by ameliorating the proteolytic and antioxidant defense systems
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DOI: 10.1002/jcp.27348
Abstract: Skeletal muscle atrophy/wasting is associated with impaired protein metabolism in diverse physiological and pathophysiological conditions. Elevated levels of reactive oxygen species (ROS), disturbed redox status, and weakened antioxidant defense system are the major contributing factors… read more here.
Keywords: skeletal muscle; muscle; antioxidant defense; atrophy ... See more keywords