Developing an atroposelective dynamic kinetic resolution of MRTX1719 by resolving incompatible chemical operations.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03627d
Abstract: A high-yielding protocol for atropisomeric resolution was developed by rectifying incompatibilities between crystallization and epimerization via continuous processing. Application toward synthesis of MRTX1719, a densely functionalized active pharmaceutical ingredient (API), improved yield from 37% to… read more here.
Keywords: mrtx1719; developing atroposelective; resolution; atroposelective dynamic ... See more keywords
Organocatalyzed atroposelective dynamic kinetic resolutions via transient seven-membered cyclic hemiacetals
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adx8255
Abstract: Catalytic atroposelective dynamic kinetic resolution via the formation of transient bridged biaryl intermediates represents an expedient route for the synthesis of axially chiral biaryls. Progress in this field has been limited to the reactions promoted… read more here.
Keywords: seven membered; atroposelective dynamic; dynamic kinetic; membered cyclic ... See more keywords