Developing an atroposelective dynamic kinetic resolution of MRTX1719 by resolving incompatible chemical operations.
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DOI: 10.1039/d2cc03627d
Abstract: A high-yielding protocol for atropisomeric resolution was developed by rectifying incompatibilities between crystallization and epimerization via continuous processing. Application toward synthesis of MRTX1719, a densely functionalized active pharmaceutical ingredient (API), improved yield from 37% to… read more here.
Keywords: mrtx1719; developing atroposelective; resolution; atroposelective dynamic ... See more keywords