Palladium/Amino Acid Co-catalyzed Atroposelective C-H Olefination to Access Tetra-Ortho-Substituted Atropisomers Featuring 2,2'-Difluoro-1-biaryl Scaffolds.
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DOI: 10.1021/acs.orglett.2c02303
Abstract: Despite the great advancement in atroposelective synthesis in the past decades, the enantioselective synthesis of 2,2'-difluoro-1-biaryls is unprecedented. Herein, a palladium and chiral amino acid catalyzed atroposelective C-H olefination to construct the axially chiral 2,2'-difluoro-1-biaryls… read more here.
Keywords: difluoro; atroposelective olefination; amino acid; catalyzed atroposelective ... See more keywords
Thioether-enabled palladium-catalyzed atroposelective C–H olefination for N–C and C–C axial chirality
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc00748g
Abstract: Thioethers allowed for highly atroposelective C–H olefinations by a palladium/chiral phosphoric acid catalytic system under ambient air. Both N–C and C–C axial chiral (hetero)biaryls were successfully constructed, leading to a broad range of axially chiral… read more here.
Keywords: palladium catalyzed; enabled palladium; atroposelective olefination; thioether enabled ... See more keywords