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   Articles with "atrt" as a keyword



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Age of diagnosis clinically differentiates atypical teratoid/rhabdoid tumors diagnosed below age of 3 years: a database study

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recommendations! Published in 2020 at "Child's Nervous System"

DOI: 10.1007/s00381-020-04972-1

Abstract: Atypical teratoid/rhabdoid tumor (ATRT) is a rare and largely pediatric diagnosis, with poor survival. Diagnosis below the age of 3 years is characteristically seen as a poor prognostic sign. However, elucidating if clinical differences exist… read more here.

Keywords: diagnosis; age; atypical teratoid; group ... See more keywords
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ATRT-13. DIFFERENT CELLS OF ORIGIN PAVE THE WAY FOR MOLECULAR HETEROGENEITY IN RHABDOID TUMORS

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recommendations! Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.012

Abstract: Abstract Rhabdoid tumors (RT) are rare but highly aggressive pediatric neoplasms. These tumors carry homozygous loss-of-function alterations of SMARCB1 in almost all cases with an otherwise low mutational load. RT arise at different intracranial (ATRT)… read more here.

Keywords: rhabdoid tumors; different cells; heterogeneity; atrt ... See more keywords
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ATRT-28. SINGLE NUCLEI SEQUENCING REVEALS THE DIFFERENT PHENOTYPIC COMPOSITION OF THE ATRT SUBGROUPS

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recommendations! Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.027

Abstract: Abstract Atypical teratoid/rhabdoid tumors (ATRT) represents a genomically homogeneous disease characterized by loss of SMARCB1 protein in the vast majority of cases. In recent years, it has become clear that these tumors display a high… read more here.

Keywords: atrt; nuclei sequencing; phenotypic composition; single nuclei ... See more keywords
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ATRT-24. CHROMATIN SEGMENTATION IN ATRT REVEALS AN IMPORTANT ROLE FOR RESIDUAL SWI/SNF MEMBERS

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recommendations! Published in 2018 at "Neuro-oncology"

DOI: 10.1093/neuonc/noy059.022

Abstract: Although SMARCB1 mutations represent the only recurrent genetic aberration in atypical teratoid/rhabdoid tumors (ATRT), a comprehensive assessment of the epigenetic effect of SMARCB1 loss has not been attempted so far. To achieve this, we performed… read more here.

Keywords: residual swi; atrt chromatin; role; chromatin segmentation ... See more keywords
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Histopathological patterns in atypical teratoid/rhabdoid tumors are related to molecular subgroup

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recommendations! Published in 2021 at "Brain Pathology"

DOI: 10.1111/bpa.12967

Abstract: Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant tumor that may not only contain rhabdoid tumor cells but also poorly differentiated small‐round‐blue cells as well as areas with mesenchymal or epithelial differentiation. Little is known… read more here.

Keywords: teratoid rhabdoid; atypical teratoid; atrt tyr; atrt ... See more keywords

Abstract 3933: RRM2 inhibition by COH29 is a potential therapeutic strategy for atypical teratoid rhabdoid tumors

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-3933

Abstract: Introduction: Atypical teratoid rhabdoid tumors (ATRT) are a rare but aggressive malignancy in central nervous system, commonly occurring in early childhood. ATRT patients face a dismal prognosis despite aggressive therapy. Development of both effective and… read more here.

Keywords: rrm2; atrt; teratoid rhabdoid; atypical teratoid ... See more keywords