Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41058-8
Abstract: Many tumors maintain chromosome-ends through a telomerase-independent, DNA-templated mechanism called alternative lengthening of telomeres (ALT). While ALT occurs in only a subset of tumors, it is strongly associated with mutations in the genes ATRX and… read more here.
Keywords: daxx; rapid reversible; atrx daxx; osteosarcoma ... See more keywords
Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size
Sign Up to like & getrecommendations! Published in 2021 at "Gut"
DOI: 10.1136/gutjnl-2020-322595
Abstract: Objective Recent studies have found aristaless-related homeobox gene (ARX)/pancreatic and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked (ATRX)/death domain-associated protein (DAXX) and alternative lengthening of telomeres (ALT) to be promising prognostic biomarkers for non-functional pancreatic… read more here.
Keywords: atrx daxx; non functional; neuroendocrine tumours; alt ... See more keywords
ATRX/DAXX: Guarding the Genome against the Hazards of ALT
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DOI: 10.3390/genes14040790
Abstract: Proliferating cells must enact a telomere maintenance mechanism to ensure genomic stability. In a subset of tumors, telomeres are maintained not by telomerase, but through a homologous recombination-based mechanism termed Alternative Lengthening of Telomeres or… read more here.
Keywords: daxx guarding; hazards alt; guarding genome; daxx ... See more keywords
Immunohistochemical analyses of the expression profiles of INSM1, ATRX, DAXX and DLL3 in solid papillary carcinomas of the breast
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DOI: 10.3892/ol.2022.13257
Abstract: Solid papillary carcinoma (SPC) is a rare but distinct clinicopathological feature of breast cancer characterised by frequent neuroendocrine differentiation. Insulinoma-associated protein 1 (INSM1) is a useful neuroendocrine marker for various neuroendocrine tumours. α-thalassemia/mental retardation syndrome… read more here.
Keywords: daxx dll3; solid papillary; insm1 atrx; expression ... See more keywords