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   Articles with "atrx mutations" as a keyword



ATRX Mutations in Pineal Parenchymal Tumors of Intermediate Differentiation.

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recommendations! Published in 2019 at "Journal of neuropathology and experimental neurology"

DOI: 10.1093/jnen/nlz050

Abstract: Pineal parenchymal tumors are rare neoplasms, ranging from WHO Grade I to IV. There are few studies characterizing the molecular profiles of these tumors. ATRX alterations are strongly associated with the presence of the alternative… read more here.

Keywords: atrx mutations; pineal parenchymal; parenchymal tumors; tumors intermediate ... See more keywords

ATRX histone binding and helicase activities have distinct roles in neuronal differentiation

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac683

Abstract: Abstract ATRX is a chromatin remodeler, which is mutated in ATRX syndrome, a neurodevelopmental disorder. ATRX mutations that alter histone binding or chromatin remodeling activities cluster in the PHD finger or the helicase domain respectively.… read more here.

Keywords: histone; helicase; atrx histone; atrx mutations ... See more keywords

ATRX mutation modifies the DNA damage response in glioblastoma multiforme tumor cells and enhances patient prognosis

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recommendations! Published in 2025 at "Medicine"

DOI: 10.1097/md.0000000000041180

Abstract: The presence of specific genetic mutations in patients with glioblastoma multiforme (GBM) is associated with improved survival outcomes. Disruption of the DNA damage response (DDR) pathway in tumor cells enhances the effectiveness of radiotherapy drugs,… read more here.

Keywords: damage; atrx mutations; tumor cells; tumor ... See more keywords

Significance of TERT and ATRX mutations in glioma

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recommendations! Published in 2019 at "Oncology Letters"

DOI: 10.3892/ol.2018.9634

Abstract: Mutations of telomerase reverse transcriptase (TERT) and the α thalassemia/mental retardation syndrome X-linked (ATRX) genes have been the subject of numerous studies on the classification and prognosis of glioma. However, the association between TERT and… read more here.

Keywords: tert atrx; atrx mutations; tert promoter; expression ... See more keywords