Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding
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DOI: 10.1172/jci.insight.151583
Abstract: Osteosarcoma (OS) is a lethal disease with few known targeted therapies. Here, we show that decreased ATRX expression is associated with more aggressive tumor cell phenotypes, including increased growth, migration, invasion, and metastasis. These phenotypic… read more here.
Keywords: aggressive features; promotes aggressive; integrin binding; loss ... See more keywords