Abstract 2935: ZW270, a conditionally masked IL-12 cytokine fusion protein displaying potent anti-tumor activity absent systemic toxicity
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DOI: 10.1158/1538-7445.am2023-2935
Abstract: IL-12 is a pleiotropic cytokine that potently stimulates anti-tumor cytotoxic T and NK cell mediated immunity. Recombinant IL-12 reduces tumor growth in multiple mouse models, but its therapeutic application has been limited by severe toxicities.… read more here.
Keywords: potency; anti tumor; att 12fc; tumor activity ... See more keywords