CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07653-5
Abstract: The membrane attack complex (MAC) is one of the immune system’s first responders. Complement proteins assemble on target membranes to form pores that lyse pathogens and impact tissue homeostasis of self-cells. How MAC disrupts the… read more here.
Keywords: attack complex; complement membrane; lipid bilayers; membrane attack ... See more keywords
Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of innate immunity"
DOI: 10.1159/000524587
Abstract: Damage and disease of nerves activates the complement system. We demonstrated that activation of the terminal pathway of the complement system leads to the formation of the membrane attack complex (MAC) and delays regeneration in… read more here.
Keywords: monoclonal antibody; disease; membrane attack; formation ... See more keywords
Complement membrane attack complex is an immunometabolic regulator of NLRP3 activation and IL-18 secretion in human macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.918551
Abstract: The complement system is an ancient and critical part of innate immunity. Recent studies have highlighted novel roles of complement beyond lysis of invading pathogens with implications in regulating the innate immune response, as well… read more here.
Keywords: complement; membrane attack; regulator; attack complex ... See more keywords
Quantitative Analysis of Complement Membrane Attack Complex Proteins Associated with Extracellular Vesicles
Sign Up to like & getrecommendations! Published in 2024 at "Proteomes"
DOI: 10.3390/proteomes12030021
Abstract: Extracellular vesicles (EVs) represent a universal mechanism of intercellular communication in normal and pathological conditions. There are reports showing the presence of complement proteins in EV preparations, specifically those that can form a membrane attack… read more here.
Keywords: extracellular vesicles; attack complex; membrane attack; complement ... See more keywords