Enhanced immune response to a dual-promoter anti-caries DNA vaccine orally delivered by attenuated Salmonella typhimurium.
Sign Up to like & getrecommendations! Published in 2017 at "Immunobiology"
DOI: 10.1016/j.imbio.2017.01.007
Abstract: The strength of immune responses induced by DNA vaccine is closely associated with the expression level of cloned antigens available to the antigen presenting cells (APCs). To acquire a larger and more persistent amount of… read more here.
Keywords: salmonella; attenuated salmonella; promoter; anti caries ... See more keywords
Engineered Attenuated Salmonella typhimurium Expressing Neoantigen Has Anticancer Effects.
Sign Up to like & getrecommendations! Published in 2021 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.1c00097
Abstract: Neoantigen vaccines are an immunotherapy strategy for treating cancer. The vaccine degrades quickly, so the strategy must include protection and precise targeting for immune cell stimulation. In this study, we engineered attenuated Salmonella typhimurium, which… read more here.
Keywords: salmonella; salmonella typhimurium; expressing neoantigen; attenuated salmonella ... See more keywords
Intratumoral injection of schwannoma with attenuated Salmonella typhimurium induces antitumor immunity and controls tumor growth
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2202719119
Abstract: Significance Neurofibromatosis type 2 (NF2) is caused by slow-growing benign schwannomas that develop throughout the body and cause severe pain, morbidity, and mortality. Surgical resection and radiotherapy are the standards of care for NF2 but… read more here.
Keywords: intratumoral injection; salmonella typhimurium; injection schwannoma; typhimurium ... See more keywords
Oral Immunization with Attenuated Salmonella Choleraesuis Expressing the P42 and P97 Antigens Protects Mice against Mycoplasma hyopneumoniae Challenge
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02361-22
Abstract: Mhp is the main pathogen of porcine enzootic pneumonia, a highly infectious and economically significant respiratory disease that affects pigs of all ages. As the target tissue of Mhp infections are the mucosal sites of… read more here.
Keywords: mhp; immunity; mucosal; salmonella ... See more keywords
IFN-γ enhances the antitumor activity of attenuated salmonella-mediated cancer immunotherapy by increasing M1 macrophage and CD4 and CD8 T cell counts and decreasing neutrophil counts
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.996055
Abstract: Bacteria-mediated cancer immunotherapy (BCI) inhibits tumor progression and has a synergistic antitumor effect when combined with chemotherapy. The anti- or pro-tumorigenic effects of interferon-γ (IFN-γ) are controversial; hence, we were interested in the antitumor effects… read more here.
Keywords: mediated cancer; tumor; attenuated salmonella; cancer immunotherapy ... See more keywords