Targeting microglia attenuates neuroinflammation‐related neural damage in mice carrying human PLP1 mutations
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23539
Abstract: Genetically caused neurological disorders of the central nervous system (CNS) usually result in poor or even fatal clinical outcome and few or no causative treatments are available. Often, these disorders are associated with disease‐amplifying neuroinflammation,… read more here.
Keywords: plp1; related neural; cns; neuroinflammation related ... See more keywords
Gastrodin attenuates neuroinflammation in DOI‐induce Tourette syndrome in rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22302
Abstract: Tourette syndrome (TS) is a chronic neuropsychiatric disorder. Its clinical manifestations are involuntary and recurrent muscle twitch, resulting in motor twitch and occurrence twitch. Traditional Chinese medicine has obvious advantages in treating TS. The aim… read more here.
Keywords: attenuates neuroinflammation; gastrodin attenuates; tourette; doi ... See more keywords
MIF downregulation attenuates neuroinflammation via TLR4/MyD88/TRAF6/NF-κB pathway to protect dopaminergic neurons in Parkinson’s disease model
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DOI: 10.1038/s42003-025-08997-7
Abstract: The progression of Parkinson’s disease (PD) is closely associated with neuroinflammatory responses and microglial activation. Consequently, research targeting microglia-mediated neuroinflammation has garnered increasing attention. Macrophage migration inhibitory factor (MIF), a multifunctional cytokine, is implicated in… read more here.
Keywords: mif; attenuates neuroinflammation; downregulation; myd88 traf6 ... See more keywords
Kv1.3 inhibition attenuates neuroinflammation through disruption of microglial calcium signaling
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DOI: 10.1080/19336950.2020.1853943
Abstract: ABSTRACT In the last 5 years inhibitors of the potassium channel KV1.3 have been shown to reduce neuroinflammation in rodent models of ischemic stroke, Alzheimer’s disease, Parkinson’s disease and traumatic brain injury. At the systemic… read more here.
Keywords: inhibition attenuates; kv1 inhibition; disruption microglial; calcium ... See more keywords