Metformin attenuates renal tubulointerstitial fibrosis via upgrading autophagy in the early stage of diabetic nephropathy
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DOI: 10.1038/s41598-021-95827-5
Abstract: This study aimed at comparing the effects of metformin on tubulointerstitial fibrosis (TIF) in different stages of diabetic nephropathy (DN) in vivo and evaluating the mechanism in high glucose (HG)-treated renal tubular epithelial cells (RTECs)… read more here.
Keywords: fibrosis; metformin; metformin attenuates; attenuates renal ... See more keywords
Interleukin-10 attenuates renal injury after myocardial infarction in diabetes
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DOI: 10.1136/jim-2021-002008
Abstract: Acute kidney injury (AKI) is a common complication after myocardial infarction (MI) and associated with significant morbidity and mortality. AKI after MI occurs more frequently in patients with diabetes, however, the underlying mechanisms are poorly… read more here.
Keywords: renal injury; diabetic mice; myocardial infarction; mice ... See more keywords
Sesamol Attenuates Renal Inflammation and Arrests Reactive-Oxygen-Species-Mediated IL-1β Secretion via the HO-1-Induced Inhibition of the IKKα/NFκB Pathway In Vivo and In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11122461
Abstract: Chronic nephritis leads to irreversible renal fibrosis, ultimately leading to chronic kidney disease (CKD) and death. Macrophage infiltration and interleukin 1β (IL-1β) upregulation are involved in inflammation-mediated renal fibrosis and CKD. Sesamol (SM), which is… read more here.
Keywords: reactive oxygen; inflammation; renal inflammation; oxygen species ... See more keywords