Advances in the treatment of hereditary transthyretin amyloidosis: A review
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DOI: 10.1002/brb3.1371
Abstract: Amyloid transthyretin amyloidosis (ATTR) is a progressive and often fatal disease caused by the buildup of mutated (hereditary ATTR [hATTR]; also known as ATTR variant [ATTRv]) or normal transthyretin (wild‐type ATTR) throughout the body. Two… read more here.
Keywords: transthyretin amyloidosis; amyloidosis; advances treatment; attr ... See more keywords
A phenomap of TTR amyloidosis to aid diagnostic screening
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DOI: 10.1002/ehf2.15143
Abstract: Cardiac amyloidosis due to transthyretin (ATTR) remains an underdiagnosed cause of cardiomyopathy. As awareness of the disease grows and referrals for ATTR increase, clinicians are likely to encounter more atypical forms of the condition in… read more here.
Keywords: disease; attr; phenomap; ttr ... See more keywords
Efficacy and safety of tafamidis doses in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR‐ACT) and long‐term extension study
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DOI: 10.1002/ejhf.2027
Abstract: Tafamidis is an effective treatment for transthyretin amyloid cardiomyopathy (ATTR‐CM) in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR‐ACT). While ATTR‐ACT was not designed for a dose‐specific assessment, further analysis from ATTR‐ACT and its long‐term… read more here.
Keywords: attr act; attr; tafamidis transthyretin; transthyretin cardiomyopathy ... See more keywords
Use of fluorine-18 sodium fluoride for the diagnosis of transthyretin cardiac amyloidosis: The birth of a new technique
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DOI: 10.1007/s12350-017-0847-6
Abstract: Imaging techniques undergo a process of development. They are birthed from an idea or a hypothesis, and then investigators look for pre-clinical models followed by publication of clinical case reports. In the adolescence of a… read more here.
Keywords: technique; medicine; cardiology; amyloidosis ... See more keywords
Optimal interpretation of Tc99m PYP in 2020: Avoiding the million-dollar mistake
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DOI: 10.1007/s12350-020-02503-8
Abstract: The diagnosis of transthyretin cardiac amyloidosis (ATTR-CA) is now literally a million-dollar implication. With the approval of tafamidis (Vyndaqel/ Vyndamax) in 2019, ATTR-CA has become a treatable chronic disease state with potentially life prolonging therapy… read more here.
Keywords: interpretation; million dollar; cardiology; pyp imaging ... See more keywords
Eplontersen: First Approval
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DOI: 10.1007/s40265-024-02008-5
Abstract: Eplontersen (Wainua™) is a ligand-conjugated antisense oligonucleotide directed to TTR, which is being developed by Ionis Pharmaceuticals and AstraZeneca for the treatment of TTR-mediated amyloidosis (ATTR). Eplontersen, which is targeted to the liver by a… read more here.
Keywords: attr; ttr; first approval; eplontersen first ... See more keywords
Evaluating Use of 99mTc-PYP Scan in Diagnosis of ATTR- A Tertiary Care Center Experience
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DOI: 10.1016/j.healun.2021.01.617
Abstract: Purpose The 99mTc-pyrophosphate (PYP) scan for the diagnosis of Transthyretin Related Cardiac Amyloidosis (ATTR) may be used in an inappropriate context or with incorrect interpretation, leading to misdiagnosis and futile financial burden. Here we report… read more here.
Keywords: scan diagnosis; attr; use; pyp scan ... See more keywords
Artificial intelligence to assist the echocardiographic identification of transthyretin cardiac amyloidosis
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DOI: 10.1093/eurheartj/ehae666.1810
Abstract: Transthyretin cardiac amyloidosis (ATTR-CM) is a severe disease, and treatments are most effective when initiated at early stage. Echocardiography is the main tool for screening patients with suspected ATTR-CM or populations at high risk of… read more here.
Keywords: artificial intelligence; attr; transthyretin cardiac; intelligence assist ... See more keywords
Characterizing the progression of subclinical cardiac amyloidosis through artificial intelligence applied to electrocardiographic images and echocardiograms
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DOI: 10.1093/eurheartj/ehae666.2089
Abstract: Transthyretin amyloid cardiomyopathy (ATTR-CM) follows an indolent course and may remain undiagnosed for many years before resulting in clinical disease. To assess the utility of scalable artificial intelligence (AI) methods applied to electrocardiographic (ECG) images… read more here.
Keywords: diagnosis; artificial intelligence; images echocardiograms; attr ... See more keywords
Single-center analysis of cardiac amyloidosis using 99mTc-HMDP imaging for diagnosis and evaluation after tafamidis treatment
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DOI: 10.1097/mnm.0000000000001922
Abstract: Objective This study aimed to evaluate the diagnostic performance of 99mTc-hydroxymethylene diphosphonate (99mTc-HMDP) imaging for cardiac amyloidosis and to demonstrate changes in cardiac uptake of 99mTc-HMDP after tafamidis treatment. Methods Seventy-five patients with suspected cardiac… read more here.
Keywords: attr; hmdp imaging; tafamidis treatment; suvpeak ... See more keywords
Concomitant ATTR and AL Cardiac Amyloidosis With Matching 99mTc-DPD Scintigraphy and 18F-Flutemetamol PET/CT.
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DOI: 10.1097/rlu.0000000000005784
Abstract: Two distinct types of systemic amyloidosis-transthyretin (ATTR) and light chain (AL)-account for the majority of cardiac amyloidosis (CA), which have been considered mutually exclusive. Diagnostic confusion can arise when both proteins are identified from an… read more here.
Keywords: attr cardiac; attr; 18f flutemetamol; cardiac amyloidosis ... See more keywords