Symptoms of Hereditary Transthyretin Amyloidosis: The Patient and Physician Perspective
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DOI: 10.1007/s40120-024-00657-y
Abstract: This article has been co-authored by a patient living with hereditary transthyretin (ATTRv) amyloidosis and a neurologist. This rare, progressive disease is associated with impairment of multiple organ systems, including the nerves, heart, and the… read more here.
Keywords: symptoms hereditary; transthyretin amyloidosis; hereditary transthyretin; attrv amyloidosis ... See more keywords
Repurposing of Agrochemicals as ATTRv Amyloidosis Inhibitors.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c02221
Abstract: Transthyretin (TTR), a plasma protein, undergoes transformation into amyloid fibers, leading to ATTRv amyloidosis, a disease characterized by organ deposition of TTR amyloid fibrils and subsequent organ failure. Developing compounds that bind and kinetically stabilize… read more here.
Keywords: fibril formation; ttr; attrv amyloidosis; formation inhibition ... See more keywords
Italian Real-Life Experience of Patients with Hereditary Transthyretin Amyloidosis Treated with Patisiran
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacogenomics and Personalized Medicine"
DOI: 10.2147/pgpm.s359851
Abstract: Abstract Hereditary transthyretin amyloidosis (ATTRv) is a multisystemic, rare, inherited, progressive and adult-onset disease, affecting the sensorimotor nerves, heart, autonomic function and other organs. The actual scenario of pharmaceutical approaches for ATTRv amyloidosis includes five… read more here.
Keywords: real life; attrv amyloidosis; hereditary transthyretin; transthyretin amyloidosis ... See more keywords
Deterioration after Liver Transplantation and Transthyretin Stabilizer Administration in a Patient with ATTRv Amyloidosis with a Leu58Arg (p.Leu78Arg) TTR Variant
Sign Up to like & getrecommendations! Published in 2022 at "Internal Medicine"
DOI: 10.2169/internalmedicine.8945-21
Abstract: We herein report a 44-year-old Japanese man with hereditary transthyretin amyloidosis (ATTRv amyloidosis) harboring the variant Leu58Arg (p.Leu78Arg) in TTR in whom we conducted an observational study with liver transplantation (LT) and transthyretin (TTR) stabilizers… read more here.
Keywords: transthyretin; ttr; attrv amyloidosis; leu58arg leu78arg ... See more keywords
Extracellular Vesicles Contribute to the Metabolism of Transthyretin Amyloid in Hereditary Transthyretin Amyloidosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.839917
Abstract: Hereditary (variant) transthyretin amyloidosis (ATTRv amyloidosis), which is caused by variants in the transthyretin (TTR) gene, leads to TTR amyloid deposits in multiple organs and various symptoms such as limb ataxia, muscle weakness, and cardiac… read more here.
Keywords: transthyretin; ttr amyloid; attrv amyloidosis; transthyretin amyloidosis ... See more keywords
Skeletal Muscle Involvement Pattern of Hereditary Transthyretin Amyloidosis: A Study Based on Muscle MRI
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.851190
Abstract: Objects This study was intended to explore the characteristics of muscle magnetic resonance imaging (MRI) of patients with hereditary transthyretin amyloidosis (ATTRv amyloidosis) prospectively. Methods The clinical data of 20 patients with ATTRv amyloidosis at… read more here.
Keywords: fatty infiltration; muscle; attrv amyloidosis; hereditary transthyretin ... See more keywords