Physicochemical characteristics of the complexes of simvastatin and atorvastatin calcium with hydroxypropyl-β-cyclodextrin produced by mechanochemical activation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2018.05.018
Abstract: Abstract In the present work, inclusion complexes of simvastatin (SIM), atorvastatin calcium (ATV) with hydroxypropyl-β-cyclodextrin (HP-β-CD) have been prepared using mechanochemistry technique to improve solubility of the two drugs and enhance their oral bioavailability. The… read more here.
Keywords: complexes simvastatin; hydroxypropyl cyclodextrin; atv; atorvastatin calcium ... See more keywords
Solubility enhancement of simvastatin and atorvastatin by arginine: A solvodynamics study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2017.05.003
Abstract: Abstract Arginine (ARG) aided solubility enhancement of statin-based model drugs such as simvastatin (SMV) and atorvastatin (ATV) has been reported. Herein, both SMV and ATV are considered as a solute, whereas ARG the cosolute. The… read more here.
Keywords: atv; arg; arginine; solubility enhancement ... See more keywords
Metal(triphenylphosphine)-atovaquone Complexes: Synthesis, Antimalarial Activity, and Suppression of Heme Detoxification
Sign Up to like & getrecommendations! Published in 2024 at "Inorganic Chemistry"
DOI: 10.1021/acs.inorgchem.4c02751
Abstract: To ascertain the bioinorganic chemistry of metals conjugated with quinones, the complexes [Ag(ATV)(PPh3)2] (1), [Au(ATV)(PPh3)]·2H2O (2), and [Cu(ATV)(PPh3)2] (3) were synthesized by the coordination of the antimalarial naphthoquinone atovaquone (ATV) to the starting materials [Ag(PPh3)2]NO3,… read more here.
Keywords: chemistry; pph3; metal; atovaquone ... See more keywords
JA:2021-11. Exposure, Crashes, and Deaths Related to the Use of All-Terrain Vehicles for Spraying
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Agromedicine"
DOI: 10.1080/1059924x.2020.1763738
Abstract: ABSTRACT Purpose: All-terrain vehicles (ATVs) are valuable assets on farms and ranches, but are associated with a growing proportion of U.S. agricultural work-related deaths and injuries. The objectives of this study were to investigate the… read more here.
Keywords: related deaths; 2021 exposure; atv; private pesticide ... See more keywords
Enhancement of the anticancer effect of atorvastatin-loaded nanoemulsions by improving oral absorption via multivalent intestinal transporter-targeting lipids
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2149896
Abstract: Abstract Atorvastatin (ATV) has attracted considerable attention as a potential therapeutic agent for cancer because it inhibits cancer cell proliferation by suppressing the mevalonate pathway. However, because of its low oral absorption, high doses of… read more here.
Keywords: atv; transporter; multivalent intestinal; intestinal transporter ... See more keywords
Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell Lines
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000001043
Abstract: Supplemental Digital Content is Available in the Text. Background: Although atorvastatin (ATV) is well-tolerated, patients may report muscle complaints. These are difficult to predict owing to high interindividual variability. Such side effects are linked to… read more here.
Keywords: slco2b1 abcc1; atv; accumulation; intracellular accumulation ... See more keywords
Specific rescue by ortho‐hydroxy atorvastatin of cortical GABAergic neurons from previous oxygen/glucose deprivation: role of pCREB
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14210
Abstract: The statin atorvastatin (ATV) given as a post-treatment has been reported beneficial in stroke, although the mechanisms involved are not well understood so far. Here, we investigated in vitro the effect of post-treatment with ATV and… read more here.
Keywords: atv; ortho hydroxy; pcreb; post ... See more keywords
The Efficacy of Oral Atorvastatin for Skin Toxicity in Breast Cancer Patients Undergoing Radiotherapy: A Randomized, Double-blind, Placebo-controlled Trial.
Sign Up to like & getrecommendations! Published in 2025 at "Current pharmaceutical design"
DOI: 10.2174/0113816128343188241225193315
Abstract: INTRODUCTION Most Breast Cancer (BC) patients undergoing Radiotherapy (RT) are potentially susceptible to skin toxicity and prone to clinical symptom complaints. This study aimed to investigate the effect of oral Atorvastatin (ATV) administration on skin… read more here.
Keywords: patients undergoing; skin toxicity; group; toxicity ... See more keywords
Combined Effect of Diosgenin Along with Ezetimibe or Atorvastatin on the Fate of Labelled Bile Acid and Cholesterol in Hypercholesterolemic Rats
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph16040627
Abstract: We analyzed the effect of diosgenin, administered with atorvastatin or ezetimibe, on the fate of 3H(G)-taurocholic acid or 26-14C-cholesterol in hypercholesterolemic rats. Male Wistar rats received a hypercholesterolemic diet (HD), HD + atorvastatin (HD+ATV), HD… read more here.
Keywords: atv; cholesterol hypercholesterolemic; effect diosgenin; diosgenin ... See more keywords
How Uremic Toxins Alter Atorvastatin Disposition: Molecular Mechanisms of Inhibition of the Enzyme CYP3A4
Sign Up to like & getrecommendations! Published in 2025 at "Balkan Medical Journal"
DOI: 10.4274/balkanmedj.galenos.2024.2024-9-12
Abstract: Background In uremic patients, the accumulation of gut-derived protein-bound uremic toxins (PBUTs) induces changes in the microenvironment of the patients, leading to changes in the elimination pattern of drugs. Aims To assess ways in which… read more here.
Keywords: uremic toxins; cyp3a4; group group; group ... See more keywords