Hepatocyte autotaxin expression promotes liver fibrosis and cancer
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28973
Abstract: Autotaxin (ATX) is a secreted lysophospholipase D that catalyzes the production of lysophosphatidic acid (LPA), a pleiotropic growth‐factor–like lysophospholipid. Increased ATX expression has been detected in various chronic inflammatory disorders and different types of cancer;… read more here.
Keywords: atx; liver fibrosis; fibrosis cancer; expression ... See more keywords
Rapidly Progressive Atypical Parkinsonism as a Presenting Feature of ATX‐CACNA1G (SCA42)
Sign Up to like & getrecommendations! Published in 2023 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13704
Abstract: Parkinsonism can be a prominent clinical manifestation of ATX-ATXN2 , ATX- ATXN3 , ATX- CACNA1A , ATX- TBP , ATX-STUB1 , and ATX- PPP2R2B with mild or absent cerebellar signs 1,2 with some cases resembling… read more here.
Keywords: atx; atypical parkinsonism; parkinsonism; rapidly progressive ... See more keywords
Autotaxin-Lysophosphatidic Acid Axis Blockade Improves Inflammation by Regulating Th17 Cell Differentiation in DSS-Induced Chronic Colitis Mice
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation"
DOI: 10.1007/s10753-019-01015-z
Abstract: Autotaxin-lysophosphatidic acid (ATX-LPA) axis is closely associated with several inflammation-related diseases. In the colonic mucosa of patients with chronic ulcerative colitis (UC), the expression of ATX and the percentage of Th17 cells are found to… read more here.
Keywords: axis; atx lpa; th17 cell; atx ... See more keywords
Establishment of a novel, cell-based autotaxin assay.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2021.114322
Abstract: Autotaxin (ATX) plays an important role in (patho-)physiological lysophosphatidic acid (LPA) signaling. Here we describe the establishment of novel cell-based ATX assay formats. ATX-mediated LPA generation is detected by using a stable LPA receptor reporter… read more here.
Keywords: atx; autotaxin; novel cell; cell based ... See more keywords
Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00368
Abstract: Autotaxin (ATX) facilitates the hydrolysis of lysophosphatidylcholine to lysophosphatidic acid (LPA), a bioactive phospholipid, which facilitates a diverse range of cellular effects in multiple tissue types. Abnormal LPA expression can lead to the progression of… read more here.
Keywords: autotaxin; based design; atx; class ... See more keywords
Hydroxamic Acids Constitute a Novel Class of Autotaxin Inhibitors that Exhibit in Vivo Efficacy in a Pulmonary Fibrosis Model.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00232
Abstract: Autotaxin (ATX) catalyzes the hydrolysis of lysophosphatidylcholine (LPC) generating the lipid mediator lysophosphatidic acid (LPA). Both ATX and LPA are involved in various pathological inflammatory conditions, including fibrosis and cancer, and have attracted great interest… read more here.
Keywords: atx; fibrosis; autotaxin; hydroxamic acids ... See more keywords
Urine autotaxin levels reflect the disease activity of sarcoidosis
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-08388-6
Abstract: Since the clinical outcome of patients with sarcoidosis is still unpredictable, a good prognostic biomarker is necessary. Autotaxin (ATX) and phosphatidylserine-specific phospholipase A1 (PS-PLA1) function as main enzymes to produce lysophospholipids (LPLs), and these enzymes… read more here.
Keywords: disease activity; activity sarcoidosis; sarcoidosis; atx ... See more keywords
Changes in serum levels of autotaxin with direct-acting antiviral therapy in patients with chronic hepatitis C
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0195632
Abstract: Sustained virological response (SVR) rates have increased remarkably since the introduction of direct-acting antiviral agents (DAAs) for chronic hepatitis C. Autotaxin (ATX) is a secreted enzyme converting lysophosphatidylcholine to lysophosphatidic acid and a newly established… read more here.
Keywords: atx; hepatitis; treatment; atx levels ... See more keywords
Serum autotaxin levels are associated with Graves' disease.
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine journal"
DOI: 10.1507/endocrj.ej18-0451
Abstract: Graves' Disease is a representative autoimmune thyroid disease that presents with hyperthyroidism. Emerging evidence has shown the involvement of lysophosphatidic acid (LPA) and its producing enzyme, autotaxin (ATX), in the pathogenesis of various diseases; among… read more here.
Keywords: atx levels; graves disease; atx; serum atx ... See more keywords
Safety and efficacy of astaxanthin‐dimethyldisuccinate (Carophyll® Stay‐Pink 10%‐CWS) for salmonids, crustaceans and other fish
Sign Up to like & getrecommendations! Published in 2019 at "EFSA Journal"
DOI: 10.2903/j.efsa.2019.5920
Abstract: Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of astaxanthin‐dimethyldisuccinate… read more here.
Keywords: atx dmds; atx; safety; salmonids crustaceans ... See more keywords
Receptor-Mediated Delivery of Astaxanthin-Loaded Nanoparticles to Neurons: An Enhanced Potential for Subarachnoid Hemorrhage Treatment
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.00989
Abstract: Astaxanthin (ATX) is a carotenoid that exerts strong anti-oxidant and anti-inflammatory property deriving from its highly unsaturated molecular structures. However, the low stability and solubility of ATX results in poor bioavailability, which markedly hampers its… read more here.
Keywords: atx; atx nps; delivery; subarachnoid hemorrhage ... See more keywords