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   Articles with "atx" as a keyword



Hepatocyte autotaxin expression promotes liver fibrosis and cancer

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recommendations! Published in 2017 at "Hepatology"

DOI: 10.1002/hep.28973

Abstract: Autotaxin (ATX) is a secreted lysophospholipase D that catalyzes the production of lysophosphatidic acid (LPA), a pleiotropic growth‐factor–like lysophospholipid. Increased ATX expression has been detected in various chronic inflammatory disorders and different types of cancer;… read more here.

Keywords: atx; liver fibrosis; fibrosis cancer; expression ... See more keywords

Rapidly Progressive Atypical Parkinsonism as a Presenting Feature of ATX‐CACNA1G (SCA42)

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recommendations! Published in 2023 at "Movement Disorders Clinical Practice"

DOI: 10.1002/mdc3.13704

Abstract: Parkinsonism can be a prominent clinical manifestation of ATX-ATXN2 , ATX- ATXN3 , ATX- CACNA1A , ATX- TBP , ATX-STUB1 , and ATX- PPP2R2B with mild or absent cerebellar signs 1,2 with some cases resembling… read more here.

Keywords: atx; atypical parkinsonism; parkinsonism; rapidly progressive ... See more keywords

A New Case Series Suggests That SCA48 (ATX/STUB1) Is Primarily a Monogenic Disorder

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recommendations! Published in 2024 at "Movement Disorders"

DOI: 10.1002/mds.29912

Abstract: Monoallelic, pathogenic STUB1 variants cause autosomal dominant cerebellar ataxia (ATX‐STUB1/SCA48). Recently, a genetic interaction between STUB1 variants and intermediate or high‐normal CAG/CAA repeats in TBP was suggested, indicating digenic inheritance or a disease‐modifying role for… read more here.

Keywords: case series; atx; series suggests; suggests sca48 ... See more keywords

Autotaxin-Lysophosphatidic Acid Axis Blockade Improves Inflammation by Regulating Th17 Cell Differentiation in DSS-Induced Chronic Colitis Mice

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recommendations! Published in 2019 at "Inflammation"

DOI: 10.1007/s10753-019-01015-z

Abstract: Autotaxin-lysophosphatidic acid (ATX-LPA) axis is closely associated with several inflammation-related diseases. In the colonic mucosa of patients with chronic ulcerative colitis (UC), the expression of ATX and the percentage of Th17 cells are found to… read more here.

Keywords: axis; atx lpa; th17 cell; atx ... See more keywords
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Establishment of a novel, cell-based autotaxin assay.

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recommendations! Published in 2021 at "Analytical biochemistry"

DOI: 10.1016/j.ab.2021.114322

Abstract: Autotaxin (ATX) plays an important role in (patho-)physiological lysophosphatidic acid (LPA) signaling. Here we describe the establishment of novel cell-based ATX assay formats. ATX-mediated LPA generation is detected by using a stable LPA receptor reporter… read more here.

Keywords: atx; autotaxin; novel cell; cell based ... See more keywords

Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators

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recommendations! Published in 2022 at "Journal of Medicinal Chemistry"

DOI: 10.1021/acs.jmedchem.2c00368

Abstract: Autotaxin (ATX) facilitates the hydrolysis of lysophosphatidylcholine to lysophosphatidic acid (LPA), a bioactive phospholipid, which facilitates a diverse range of cellular effects in multiple tissue types. Abnormal LPA expression can lead to the progression of… read more here.

Keywords: autotaxin; based design; atx; class ... See more keywords

Hydroxamic Acids Constitute a Novel Class of Autotaxin Inhibitors that Exhibit in Vivo Efficacy in a Pulmonary Fibrosis Model.

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recommendations! Published in 2018 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.8b00232

Abstract: Autotaxin (ATX) catalyzes the hydrolysis of lysophosphatidylcholine (LPC) generating the lipid mediator lysophosphatidic acid (LPA). Both ATX and LPA are involved in various pathological inflammatory conditions, including fibrosis and cancer, and have attracted great interest… read more here.

Keywords: atx; fibrosis; autotaxin; hydroxamic acids ... See more keywords

Urine autotaxin levels reflect the disease activity of sarcoidosis

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recommendations! Published in 2022 at "Scientific Reports"

DOI: 10.1038/s41598-022-08388-6

Abstract: Since the clinical outcome of patients with sarcoidosis is still unpredictable, a good prognostic biomarker is necessary. Autotaxin (ATX) and phosphatidylserine-specific phospholipase A1 (PS-PLA1) function as main enzymes to produce lysophospholipids (LPLs), and these enzymes… read more here.

Keywords: disease activity; activity sarcoidosis; sarcoidosis; atx ... See more keywords

Pancreatic CAF-derived Autotaxin (ATX) drives autocrine CTGF expression to modulate pro-tumorigenic signaling

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recommendations! Published in 2024 at "Molecular cancer therapeutics"

DOI: 10.1158/1535-7163.mct-23-0522

Abstract: Autotaxin (ATX), encoded by ENPP2, is a clinical target in pancreatic ductal adenocarcinoma (PDAC). ATX catalyzes the production of lysophosphatidic acid (LPA), an important regulator within the tumor microenvironment (TME), yet the pro-tumorigenic action of… read more here.

Keywords: pro tumorigenic; caf derived; atx; lpa ... See more keywords

OR22-05 Weight Loss and Change in Body Composition in a DIO Mouse Model by the Combined AMPK and Mitochondrial Activator, ATX-304, Alone, in Combination With Semaglutide, and After Semaglutide Withdrawal

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recommendations! Published in 2025 at "Journal of the Endocrine Society"

DOI: 10.1210/jendso/bvaf149.080

Abstract: Abstract Disclosure: E.J. Schneider: Amplifier Therapeutics AB (affiliated employee), Cambrian BioPharma, Inc (employee, shareholder). J.A. Hall: Amplifier Therapeutics AB (employee, shareholder). G. Bor: Gubra (employee). D. Jacobs: Amplifier Therapeutics AB (employee), Cambrian BioPharma, Inc (shareholder).… read more here.

Keywords: loss; weight loss; atx; sema ... See more keywords

Changes in serum levels of autotaxin with direct-acting antiviral therapy in patients with chronic hepatitis C

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recommendations! Published in 2018 at "PLoS ONE"

DOI: 10.1371/journal.pone.0195632

Abstract: Sustained virological response (SVR) rates have increased remarkably since the introduction of direct-acting antiviral agents (DAAs) for chronic hepatitis C. Autotaxin (ATX) is a secreted enzyme converting lysophosphatidylcholine to lysophosphatidic acid and a newly established… read more here.

Keywords: atx; hepatitis; treatment; atx levels ... See more keywords