Autotaxin-Lysophosphatidic Acid Axis Blockade Improves Inflammation by Regulating Th17 Cell Differentiation in DSS-Induced Chronic Colitis Mice
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation"
DOI: 10.1007/s10753-019-01015-z
Abstract: Autotaxin-lysophosphatidic acid (ATX-LPA) axis is closely associated with several inflammation-related diseases. In the colonic mucosa of patients with chronic ulcerative colitis (UC), the expression of ATX and the percentage of Th17 cells are found to… read more here.
Keywords: axis; atx lpa; th17 cell; atx ... See more keywords
Evaluation of serum ATX and LPA as potential diagnostic biomarkers in patients with pancreatic cancer
Sign Up to like & getrecommendations! Published in 2021 at "BMC Gastroenterology"
DOI: 10.1186/s12876-021-01635-6
Abstract: Background Pancreatic cancer (PC) is a devastating disease that has a poor prognosis and a total 5-year survival rate of around 5%. The poor prognosis of PC is due in part to a lack of… read more here.
Keywords: atx lpa; ca19; pancreatic cancer; serum ... See more keywords
Roles of Autotaxin/Autotaxin-Lysophosphatidic Acid Axis in the Initiation and Progression of Liver Cancer
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DOI: 10.3389/fonc.2022.922945
Abstract: Autotaxin (ATX) is a secreted glycoprotein and catalyzes the hydrolysis of lysophosphatidylcholine to lysophosphatidic acid (LPA), a growth factor-like signaling phospholipid. ATX has been abundantly detected in the culture medium of various cancer cells, tumor… read more here.
Keywords: atx; lysophosphatidic acid; lpa axis; atx lpa ... See more keywords
ATX-LPA axis facilitates estrogen-induced endometrial cancer cell proliferation via MAPK/ERK signaling pathway
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DOI: 10.3892/mmr.2018.8392
Abstract: Autotaxin (ATX) is a key enzyme that converts lysophosphatidylcholine to lysophosphatidic acid (LPA). ATX is a crucial factor that facilitates cancer progression; however, the effect of ATX on endometrial cancer has not been explored. The… read more here.
Keywords: cell proliferation; atx lpa; endometrial cancer; cancer ... See more keywords