A critical role for expression of atypical chemokine receptor 2 in multiple sclerosis: A preliminary project.
Sign Up to like & getrecommendations! Published in 2019 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2019.101524
Abstract: BACKGROUND ACKR2 is an atypical chemokine receptor that promotes acute inflammation by acting as a scavenger receptor for inflammatory chemokines in experimental models of some inflammatory disorders, but its function in multiple sclerosis (MS) is… read more here.
Keywords: atypical chemokine; multiple sclerosis; expression; receptor ... See more keywords
Deletion of atypical chemokine receptor 3 (ACKR3) increases immune cells at the fetal-maternal interface.
Sign Up to like & getrecommendations! Published in 2020 at "Placenta"
DOI: 10.1016/j.placenta.2020.04.007
Abstract: Establishment of immune cell populations and adaptations in immune cells are critical aspects during pregnancy that lead to protection of the semi-allogenic fetus. Appropriate immune cell activation and trophoblast migration are regulated in part by… read more here.
Keywords: atypical chemokine; receptor; immune cells; chemokine receptor ... See more keywords
GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2021596118
Abstract: Significance G protein–coupled receptors (GPCRs) are important regulators of cellular and biological functions and are primary targets of therapeutic drugs. About 100 mammalian GPCRs are still considered orphan receptors because they lack a known endogenous… read more here.
Keywords: receptor; atypical chemokine; hematopoietic stem; gpr182 ... See more keywords
The Atypical Chemokine Receptor ACKR2 is Protective Against Sepsis
Sign Up to like & getrecommendations! Published in 2018 at "SHOCK"
DOI: 10.1097/shk.0000000000000969
Abstract: ABSTRACT Sepsis is a systemic inflammatory response as a result of uncontrolled infections. Neutrophils are the first cells to reach the primary sites of infection, and chemokines play a key role in recruiting neutrophils. However,… read more here.
Keywords: sepsis; ackr2; atypical chemokine; mice ... See more keywords
ACKR2: An Atypical Chemokine Receptor Regulating Lymphatic Biology
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2016.00691
Abstract: The lymphatic system plays an important role in the induction of the immune response by transporting antigens, inflammatory mediators, and leukocytes from peripheral tissues to draining lymph nodes. It is emerging that lymphatic endothelial cells… read more here.
Keywords: atypical chemokine; biology; ackr2 atypical; role ... See more keywords
The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1054260
Abstract: Herpes stromal keratitis (HSK) is a blinding corneal disease caused by herpes simplex virus-1 (HSV-1), a common pathogen infecting most of the world’s population. Inflammation in HSK is chemokine-dependent, particularly CXCL10 and less so the… read more here.
Keywords: stromal keratitis; atypical chemokine; chemokine receptor; receptor ... See more keywords
The Role of Atypical Chemokine Receptor D6 (ACKR2) in Physiological and Pathological Conditions; Friend, Foe, or Both?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.861931
Abstract: Chemokines exert crucial roles in inducing immune responses through ligation to their canonical receptors. Besides these receptors, there are other atypical chemokine receptors (ACKR1–4) that can bind to a wide range of chemokines and carry… read more here.
Keywords: role atypical; atypical chemokine; tumor; tumor promoting ... See more keywords
Biphasic Expression of Atypical Chemokine Receptor (ACKR) 2 and ACKR4 in Colorectal Neoplasms in Association with Histopathological Findings
Sign Up to like & getrecommendations! Published in 2020 at "Biomolecules"
DOI: 10.3390/biom11010008
Abstract: Facilitating resolution of inflammation using atypical chemokine receptors (ACKR) as an anticancer strategy is considered but requires a deeper understanding of receptor role in carcinogenesis. We aimed at transcriptional analysis (RTqPCR) of ACKR2 and ACKR4… read more here.
Keywords: atypical chemokine; tissue; ackr4 expression; expression ... See more keywords