CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation.
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DOI: 10.1002/1878-0261.13438
Abstract: Cyclin-dependent kinases (CDKs), together with their cyclin partners, are the master cell cycle regulators. Remarkably, the cyclin family was extended to include atypical cyclins, characterized by distinctive structural features, but their partner CDKs remain elusive.… read more here.
Keywords: cell; cdk6; cancer cell; cyclin ... See more keywords