The Dual Roles of the Atypical Protein Kinase Cs in Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer cell"
DOI: 10.1016/j.ccell.2019.07.010
Abstract: Atypical protein kinase C (aPKC) isozymes, PKCλ/ι and PKCζ, are now considered fundamental regulators of tumorigenesis. However, the specific separation of functions that determine their different roles in cancer is still being unraveled. Both aPKCs… read more here.
Keywords: cancer; atypical protein; dual roles; protein kinase ... See more keywords
Human placenta and trophoblasts simultaneously express three isoforms of atypical protein kinase-c.
Sign Up to like & getrecommendations! Published in 2022 at "Placenta"
DOI: 10.1016/j.placenta.2022.01.015
Abstract: Atypical protein kinase-c (aPKC) isoforms are important regulators of polarity and stem cell differentiation. There are three isoforms of aPKC: aPKC-ι, aPKC-ζ, and PKM-ζ. Recently, aPKC-ι was shown to regulate human trophoblast stem cell (TSC)… read more here.
Keywords: atypical protein; protein kinase; three isoforms; apkc ... See more keywords
Histone acetylation determines transcription of atypical protein kinases in rat neurons
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40823-z
Abstract: It is widely accepted that memory consolidation requires de-novo transcription of memory-related genes. Epigenetic modifications, particularly histone acetylation, may facilitate gene transcription, but their potential molecular targets are poorly characterized. In the current study, we… read more here.
Keywords: transcription; histone acetylation; atypical protein; protein kinases ... See more keywords
Abstract 5022: Atypical protein kinase C inhibitors abrogate malignant breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5022
Abstract: Breast cancer is the most common cancer type with expected cases of approximately 284,200 according to the National Cancer Institute. Atypical Protein Kinase C (aPKC) plays a significant role in many cancer types. A positive… read more here.
Keywords: atypical protein; malignant breast; cell; breast cancer ... See more keywords