Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.281
Abstract: This report describes phase 1 clinical trials performed to assess interactions of oral isavuconazole at the clinically targeted dose (200 mg, administered as isavuconazonium sulfate 372 mg, 3 times a day for 2 days; 200… read more here.
Keywords: auc reduced; methadone; auc; substrates bupropion ... See more keywords
EXCEPTIONAL RESPONSE OF REFRACTORY ATLL WITH MDM4 AMPLIFICATION TO NOVEL STAPLED PEPTIDE DUAL MDM4/2 INHIBITOR
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.210_2631
Abstract: to quantify sources of variability, including body size effects, on ADC and monomethyl auristatin E (MMAE) PK in paediatric pts with classical Hodgkin lymphoma (cHL). Methods: POPPK base-models were based on previously reported models. A… read more here.
Keywords: mdm4; model; auc; based dosing ... See more keywords
Performance of predictive tools to identify individuals at risk of non-traumatic fracture: a systematic review, meta-analysis, and meta-regression
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DOI: 10.1007/s00198-019-04919-6
Abstract: SummaryThere is no consensus on which tool is the most accurate to assess fracture risk. The results of this systematic review suggest that QFracture, Fracture Risk Assessment Tool (FRAX) with BMD, and Garvan with BMD… read more here.
Keywords: garvan; fracture; bmd; meta ... See more keywords
Correlation between pharmacokinetic parameters of 5-fluorouracil and related metabolites and adverse reactions in East-Asian patients with advanced colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-021-04387-y
Abstract: To examine the range of the area under the concentration–time curve (AUC) calculated using plasma 5-FU concentration at steady-state plasma concentration–time of 5-fluorouracil (5-FU) and correlation between 5-FU metabolites (5,6-dihydro-5-fluorouracil, 5-FUH2 and α-fluoro-β-Alanine, FBAL) plasma… read more here.
Keywords: cancer; correlation; auc; concentration ... See more keywords
Identification of clusters in multifocal electrophysiology recordings to maximize discriminant capacity (patients vs. control subjects)
Sign Up to like & getrecommendations! Published in 2019 at "Documenta Ophthalmologica"
DOI: 10.1007/s10633-019-09720-8
Abstract: Purpose To propose a new method of identifying clusters in multifocal electrophysiology (multifocal electroretinogram: mfERG; multifocal visual-evoked potential: mfVEP) that conserve the maximum capacity to discriminate between patients and control subjects. Methods The theoretical framework… read more here.
Keywords: clusters multifocal; patients control; capacity; control subjects ... See more keywords
A multi-level knee point based multi-objective evolutionary algorithm for AUC maximization
Sign Up to like & getrecommendations! Published in 2019 at "Memetic Computing"
DOI: 10.1007/s12293-019-00280-7
Abstract: The area under receiver operating characteristic curve (AUC) is one of the widely used metrics for measuring imbalanced data classification results. Designing multi-objective evolutionary algorithms for AUC maximization problem has attracted much attention of researchers… read more here.
Keywords: auc maximization; objective evolutionary; auc; knee ... See more keywords
Multiparametric ultrasound evaluation with CEUS and shear wave elastography for carotid plaque risk stratification
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Ultrasound"
DOI: 10.1007/s40477-018-0320-7
Abstract: PurposeTo assess the diagnostic effectiveness of Multiparametric ultrasound (MPUS), which includes color Doppler ultrasound (CDUS), CEUS and Shear wave elastography (SWE), for evaluating carotid plaque as compared with CT-angiography (CTA) and histology.Materials and methodsForty-three consecutive… read more here.
Keywords: del; ppv; ceus; plaque ... See more keywords
Clinical benefits of natriuretic peptides and galectin-3 are maintained in old dyspnoeic patients.
Sign Up to like & getrecommendations! Published in 2017 at "Archives of gerontology and geriatrics"
DOI: 10.1016/j.archger.2016.08.010
Abstract: BACKGROUND Acute dyspnoea is the leading cause of unscheduled admission of elderly patients. Several biomarkers are used to diagnose acute heart failure (AHF) and assess prognosis of dyspnoeic patients, but their value in elderly patients… read more here.
Keywords: clinical benefits; old dyspnoeic; auc; dyspnoeic patients ... See more keywords
Comparison of the ability to identify arterial stiffness between two new anthropometric indices and classical obesity indices in Chinese adults.
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DOI: 10.1016/j.atherosclerosis.2017.06.031
Abstract: BACKGROUND AND AIMS The association between anthropometric indices of body composition and arterial stiffness is inconclusive. The objective of this study was to examine the predictive ability of two new obesity indices: a body shape… read more here.
Keywords: stiffness; anthropometric indices; linear regression; arterial stiffness ... See more keywords
Glioblastoma and primary central nervous system lymphoma: Preoperative differentiation by using MRI-based 3D texture analysis
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2018.08.004
Abstract: OBJECTIVES To investigate the diagnostic value of magnetic resonance imaging (MRI)-based 3D texture and shape features in the differentiation of glioblastoma (GBM) and primary central nervous system lymphoma (PCNSL). PATIENTS AND METHODS A total of… read more here.
Keywords: based texture; mri based; analysis; primary central ... See more keywords
A Comparison of Multiple Allergen Simultaneous Tests Using Allergen-Specific IgE Concentration and Intradermal Skin Tests in Atopic Horses With Pollen Allergy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of equine veterinary science"
DOI: 10.1016/j.jevs.2020.102992
Abstract: Intradermal tests (IDTs) and measurement of specific immunoglobulin E class (sIgE) levels in sera are the most common and reliable methods used in allergological clinical practice. The purpose of this study was to explore the… read more here.
Keywords: idt; mast; pollen allergy; auc ... See more keywords