Assessment of micafungin loading dosage regimens against Candida spp. in ICU patients by Monte Carlo simulations
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-020-02840-0
Abstract: To assess the efficacy of loading dose on micafungin by simulating different dosage regimens. A published study of micafungin in ICU patients was employed to simulate nine different dosage regimens which were sorted out three… read more here.
Keywords: auc mic; candida spp; icu patients; dosage ... See more keywords
1304. Characterization of Tebipenem Pivoxil Hydrobromide Pharmacokinetics-Pharmacodynamics (PK-PD) in a Neutropenic Murine Acute Pyelonephritis (AP) Model
Sign Up to like & getrecommendations! Published in 2020 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofaa439.1487
Abstract: Tebipenem pivoxil hydrobromide (tebipenem HBr), an orally (PO) bioavailable prodrug of tebipenem, is a carbapenem with broad-spectrum activity against Gram-positive and -negative bacteria that is being developed for the treatment of patients with complicated urinary… read more here.
Keywords: auc mic; tebipenem; tebipenem hbr; drug ... See more keywords
Pharmacodynamic Optimization for the Treatment of Invasive Candida auris Infection
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DOI: 10.1093/ofid/ofx163.004
Abstract: Abstract Background Candida auris is an emerging, nosocomial multidrug-resistant threat with high treatment failure rate and mortality. The optimal antifungal agent to use and susceptibility breakpoints are based on limited clinical data. Methods Nine clinical… read more here.
Keywords: log kill; cmax mic; auc mic; treatment ... See more keywords
1383. In vivo Pharmacokinetic/Pharmacodynamic (PK/PD) Evaluation of NOSO-502, a First-in-Class Odilorhabdin Antibiotic, Against E. coli (EC) and K. pneumoniae (KPN) in the Murine Neutropenic Thigh Model
Sign Up to like & getrecommendations! Published in 2018 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofy210.1214
Abstract: Abstract Background NOSO-502 is a novel, first-in-class Odilorhabdin antibiotic targeting bacterial protein translation, with potent in vitro activity against Enterobacteriaceae including strains with MDR or CRE-phenotype. The goal of this study was to determine the… read more here.
Keywords: research; murine; noso 502; auc mic ... See more keywords
New Recommendations of a Height-Based Dosing Regimen of Tobramycin for Cystic Fibrosis in Adults: A Population Pharmacokinetic Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000001021
Abstract: Supplemental Digital Content is Available in the Text. Background: Acute pulmonary exacerbations (APEs) in patients with adult cystic fibrosis (CF) are treated with a beta-lactam and an aminoglycoside for activity against Pseudomonas aeruginosa (PA). Emerging… read more here.
Keywords: auc mic; population pharmacokinetic; model; population ... See more keywords
Population Pharmacodynamics of Amphotericin B Deoxycholate for Disseminated Infection Caused by Talaromyces marneffei
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01739-18
Abstract: Amphotericin B deoxycholate (DAmB) is a first-line agent for the initial treatment of talaromycosis. However, little is known about the population pharmacokinetics and pharmacodynamics of DAmB for talaromycosis. ABSTRACT Amphotericin B deoxycholate (DAmB) is a… read more here.
Keywords: talaromycosis; auc mic; time; amphotericin deoxycholate ... See more keywords
In Vivo Pharmacodynamic Evaluation of Omadacycline (PTK 0796) against Streptococcus pneumoniae in the Murine Pneumonia Model
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02368-16
Abstract: ABSTRACT Omadacycline is a novel aminomethylcycline antibiotic in clinical development for community-acquired bacterial pneumonia (CABP). We used a neutropenic murine pneumonia infection model to characterize the in vivo pharmacodynamic activity of omadacycline against Streptococcus pneumoniae.… read more here.
Keywords: auc mic; omadacycline; model; vivo pharmacodynamic ... See more keywords
AUC/MIC Pharmacodynamic Target Is Not a Good Predictor of Vancomycin Efficacy in Methicillin-Resistant Staphylococcus aureus Experimental Endocarditis
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02486-16
Abstract: ABSTRACT The aim of this in vivo study was to compare the efficacy of vancomycin at standard doses (VAN-SD) to that of VAN at adjusted doses (VAN-AD) in achieving a VAN area under the curve/MIC… read more here.
Keywords: auc mic; efficacy; methicillin resistant; experimental endocarditis ... See more keywords
Evaluation of Therapeutic Vancomycin Monitoring in Taiwan
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DOI: 10.1128/spectrum.01562-21
Abstract: Since 2020, the Infectious Diseases Society of America (IDSA) updated vancomycin guidelines, and vancomycin AUC therapeutic drug monitor was updated to AUC/MIC in the United States. But acceptable rate of infection physicians in Taiwan was… read more here.
Keywords: taiwan; vancomycin; monitoring; auc mic ... See more keywords
Safety and Feasibility Assessment of a Pharmacy-Driven AUC/MIC Vancomycin Dosing Protocol in a Multicenter Hospital System
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03313-22
Abstract: In this article, we report that there were no differences in rates of acute kidney injury between trough-based vancomycin dosing and AUC/MIC-based vancomycin dosing across 12 hospitals. AUC/MIC dosing resulted in more vancomycin lab draws… read more here.
Keywords: lab; vancomycin; vancomycin dosing; auc mic ... See more keywords
Are Vancomycin Trough Concentrations of 15 to 20 mg/L Associated With Increased Attainment of an AUC/MIC ≥ 400 in Patients With Presumed MRSA Infection?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmacy Practice"
DOI: 10.1177/0897190016642692
Abstract: Purpose: To determine whether there is an association between higher vancomycin trough concentrations and attainment of a calculated area under the concentration–time curve (AUC)/minimum inhibitory concentration (MIC) ≥400. Methods: A retrospective analysis was conducted among… read more here.
Keywords: vancomycin trough; auc mic; trough concentrations; mic 400 ... See more keywords