Strategy for the Prediction of Steady-State Exposure of Digoxin to Determine Drug–Drug Interaction Potential of Digoxin With Other Drugs in Digitalization Therapy
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Therapeutics"
DOI: 10.1097/mjt.0000000000000435
Abstract: Digoxin, a narrow therapeutic index drug, is widely used in congestive heart failure. However, the digitalization therapy involves dose titration and can exhibit drug–drug interaction. Ctrough versus area under the plasma concentration versus time curve… read more here.
Keywords: versus; auc0 24h; digoxin; drug interaction ... See more keywords
Population pharmacokinetics and dose evaluations of linezolid in the treatment of multidrug-resistant tuberculosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1032674
Abstract: Background: The pharmacokinetic/pharmacodynamics (PK/PD) target derived from the hollow-fiber system model for linezolid for treatment of the multidrug-resistant tuberculosis (MDR-TB) requires clinical validation. Therefore, this study aimed to develop a population PK model for linezolid… read more here.
Keywords: linezolid treatment; treatment multidrug; population; model ... See more keywords