Chemical Modifications Reduce Auditory Cell Damage Induced by Aminoglycoside Antibiotics.
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DOI: 10.1021/jacs.9b12420
Abstract: Although aminoglycoside antibiotics are effective against Gram-negative infections, these drugs often cause irreversible hearing damage. Binding to the decoding site of eukaryotic ribosomes appears to result in ototoxicity, but there is evidence that other effects… read more here.
Keywords: aminoglycoside antibiotics; reduce auditory; chemical modifications; auditory cell ... See more keywords