mTORC2 Regulates Actin Polymerization in Auditory Cells
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DOI: 10.1111/jnc.70012
Abstract: Mammalian target of rapamycin complex 2 (mTORC2) is essential for hearing by regulating auditory hair cell structure and function. However, mechanistic details of how mTORC2 regulates intracellular processes in sensory hair cells have not yet… read more here.
Keywords: auditory; auditory cells; actin polymerization; mtorc2 regulates ... See more keywords
NPC1 Deficiency Contributes to Autophagy-Dependent Ferritinophagy in HEI-OC1 Auditory Cells
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DOI: 10.3389/fmolb.2022.952608
Abstract: Niemann–Pick type C disease (NPCD) is a rare genetic syndrome characterized by cholesterol accumulation in multiple organelles. NPCD is mainly caused by gene deficiency of NPC intracellular cholesterol transporter 1 (NPC1). It has been reported… read more here.
Keywords: autophagy dependent; dependent ferritinophagy; deficiency; auditory cells ... See more keywords
Caspase-8 Regulates Endoplasmic Reticulum Stress-Induced Necroptosis Independent of the Apoptosis Pathway in Auditory Cells
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DOI: 10.3390/ijms20235896
Abstract: The aim of this study is to elucidate the detailed mechanism of endoplasmic reticulum (ER) stress-induced auditory cell death based on the function of the initiator caspases and molecular complex of necroptosis. Here, we demonstrated… read more here.
Keywords: caspase; apoptosis; necroptosis; auditory cells ... See more keywords