Structure-guided improvement in the enantioselectivity of an Aspergillus usamii epoxide hydrolase for the gram-scale kinetic resolution of ortho-trifluoromethyl styrene oxide.
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DOI: 10.1016/j.enzmictec.2021.109778
Abstract: Microtuning the substrate-binding pocket (SBP) of EHs has emerged as an effective approach to manipulate their enantio- or regio-selectivities and activities towards target substrates. Here, the enantioselectivity (enantiomeric ratio, E) of AuEH2 towards a racemic… read more here.
Keywords: styrene oxide; kinetic resolution; trifluoromethyl styrene; aueh2r322v l344c ... See more keywords