Therapeutics: Alpha-1 Antitrypsin Augmentation Therapy.
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DOI: 10.1007/978-1-4939-7163-3_25
Abstract: Subjects with alpha-1 antitrypsin deficiency who develop pulmonary disease are managed following general treatment guidelines, including disease management interventions. In addition, administration of intravenous infusions of alpha-1 proteinase inhibitor (augmentation therapy) at regular schedules is… read more here.
Keywords: alpha antitrypsin; therapeutics alpha; therapy; augmentation therapy ... See more keywords
Real-world effectiveness and safety of aripiprazole augmentation therapy in patients with major depressive disorder
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DOI: 10.1080/03007995.2018.1519317
Abstract: Abstract Aims: Augmentation therapy is an option for patients with major depressive disorder who do respond sufficiently to adequate dosages of selective serotonin reuptake inhibitors or serotonin–norepinephrine reuptake inhibitors, but little is known about application… read more here.
Keywords: safety; augmentation; patients major; therapy ... See more keywords
Analysis of medical malpractice litigation following vertebral augmentation therapy in China from 2008 to 2018
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DOI: 10.1097/md.0000000000030972
Abstract: The first case of vertebral augmentation therapy in mainland China was reported in 2000. Since then, it has been widely used in China as a minimally invasive procedure to treat vertebral compression fractures. However, the… read more here.
Keywords: china; litigation; augmentation therapy; vertebral augmentation ... See more keywords
Use of liothyronine (L-T3) as an augmentation therapy for depression during pregnancy
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DOI: 10.1136/bcr-2018-225852
Abstract: The thyroid hormone triiodothyronine (T3) can be used as an augmentation therapy for depression. This case involves a patient who had been initiated on liothyronine (L-T3) for this purpose and subsequently became pregnant. The exogenous… read more here.
Keywords: augmentation therapy; depression; therapy depression; pregnancy ... See more keywords
Brexpiprazole augmentation and mitochondrial gene expression changes in major depressive disorder
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DOI: 10.1177/02698811251337365
Abstract: Background: Overall, 20% of patients with major depressive disorder (MDD) are treatment-resistant and do not respond to multiple antidepressant monotherapies. For such patients, augmentation therapy with antipsychotics is one of the therapeutic options. However, the… read more here.
Keywords: augmentation therapy; depressive disorder; major depressive; augmentation ... See more keywords
Impact of alpha 1-antitrypsin deficiency and prior augmentation therapy on patients' survival after lung transplantation
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/13993003.00962-2017
Abstract: Alpha 1-antitrypsin (AAT) deficiency (AATD) is a genetic condition characterised by low serum levels of AAT and is associated with a high risk of developing early-onset pulmonary emphysema, especially in cigarette smokers [1]. The most… read more here.
Keywords: aatd; therapy; augmentation therapy; deficiency ... See more keywords
Antitrypsin deficiency: still more to learn about the lung after 60 years
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DOI: 10.1183/23120541.00139-2024
Abstract: The past 60 years have seen multiple publications related to lung disease in α1-antitrypsin deficiency largely reflecting the pathophysiology, biochemical effect and outcomes of augmentation therapy. However, the complexity of disease phenotype and the impact of… read more here.
Keywords: augmentation therapy; antitrypsin deficiency; history; natural history ... See more keywords
Long-term effect of α1-antitrypsin augmentation therapy on the decline of FEV1 in deficient patients: an analysis of the AIR database
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DOI: 10.1183/23120541.00194-2021
Abstract: Background Patients with ZZ (Glu342Lys) α-1-antitrypsin deficiency (ZZ-AATD) who received augmentation therapy with α-1-antitrypsin (AAT) in randomised controlled trials over 2–3 years failed to show a significant reduction of the annual decline of forced expiratory volume… read more here.
Keywords: decline; augmentation therapy; decline fev1; augmentation ... See more keywords
Research Models and Gene Augmentation Therapy for CRB1 Retinal Dystrophies
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DOI: 10.3389/fnins.2020.00860
Abstract: Retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA) are inherited degenerative retinal dystrophies with vision loss that ultimately lead to blindness. Several genes have been shown to be involved in early onset retinal dystrophies, including… read more here.
Keywords: retinal dystrophies; gene augmentation; therapy; augmentation therapy ... See more keywords
Mitigating the Risk of Adverse Effects Related to Augmentation Therapy for Resistant Major Depressive Disorder: A Case Report
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DOI: 10.3390/medicina58030438
Abstract: Polypharmacy of psychotropic medications predisposes older adults to adverse drug events (ADEs). One contributing factor is inhibition of metabolic pathways between substrates (competitive inhibition) or between substrates and inhibitors of the same cytochrome P450 (CYP450)… read more here.
Keywords: case report; augmentation therapy; resistant major; therapy ... See more keywords
Phenotypic Expression of Respiratory Diseases and Tailored Treatment in Patients with Intermediate Alpha-1 Antitrypsin Deficiency: Evidence from a Retrospective Analysis of a Selected Cohort of Patients
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DOI: 10.3390/medicina61101747
Abstract: Introduction: Alpha-1 antitrypsin deficiency (AATD) is a genetic condition caused by SERPINA1 variants with variable severity. Current international guidelines do not recommend augmentation therapy for intermediate AATD; nevertheless, some patients show clinically severe phenotypes in… read more here.
Keywords: augmentation therapy; alpha antitrypsin; therapy; antitrypsin deficiency ... See more keywords