Investigation of pharmacokinetic and clinical outcomes of various meropenem regimens in patients with ventilator-associated pneumonia and augmented renal clearance.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of clinical pharmacology"
DOI: 10.1007/s00228-022-03291-5
Abstract: INTRODUCTION Augmented renal clearance (ARC) defined as creatinine clearance (Clcr) above 130 mL/min/1.73m2 may lead to suboptimal antibacterial treatment. The aim of this study was to determine a strategy for meropenem administration to achieve both pharmacodynamic-pharmacokinetic… read more here.
Keywords: group; clearance; renal clearance; clinical outcomes ... See more keywords
Augmented renal clearance: a common condition in critically ill children
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Nephrology"
DOI: 10.1007/s00467-019-04205-x
Abstract: BackgroundAugmented renal clearance (ARC), an increase in kidney function with enhanced elimination of circulating solute, has been increasingly recognized in critically ill adults. In a pediatric intensive care setting, data are scarce. The primary objective… read more here.
Keywords: ill children; critically ill; renal clearance; schwartz formula ... See more keywords
Population Pharmacokinetics of Levetiracetam in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage Exhibiting Augmented Renal Clearance
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacokinetics"
DOI: 10.1007/s40262-020-00979-8
Abstract: Background and Objective Patients with severe trauma exhibit augmented renal clearance, which can alter the dosing requirement of renally eliminated drugs. This study aimed to develop a population pharmacokinetic model for levetiracetam in patients with… read more here.
Keywords: traumatic brain; subarachnoid hemorrhage; renal clearance; clearance ... See more keywords
Pharmacokinetics and Pharmacodynamics of Ceftolozane/Tazobactam in Critically Ill Patients With Augmented Renal Clearance.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2021.106299
Abstract: OBJECTIVE To determine whether established ceftolozane/tazobactam (C/T) dosing is adequate among patients with augmented renal clearance (ARC) and bacterial infection. METHODS ARC (creatinine clearance [CrCl] ≥130 mL/min) was confirmed by directly measured CrCl in 11… read more here.
Keywords: ceftolozane tazobactam; renal clearance; clearance; patients augmented ... See more keywords
1364: AMINOGLYCOSIDE CLEARANCE MAY BE USEFUL TO DETECT AUGMENTED RENAL CLEARANCE IN THE CRITICALLY ILL
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000529367.48490.84
Abstract: Critical Care Medicine • Volume 46 • Number 1 (Supplement) www.ccmjournal.org Learning Objectives: Augmented renal clearance (ARC) is a syndrome characterized by enhanced glomerular filtration of solutes and medications in the nephron. ARC has been… read more here.
Keywords: medicine; arctic score; critically ill; renal clearance ... See more keywords
Identifying augmented renal clearance in trauma patients: Validation of the Augmented Renal Clearance in Trauma Intensive Care scoring system
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000001387
Abstract: BACKGROUND Augmented renal clearance (ARC) is common in trauma patients and associated with subtherapeutic antimicrobial concentrations. This study reported the incidence of ARC, identified ARC risk factors, and described a model to predict ARC (i.e.,… read more here.
Keywords: system; trauma; trauma patients; renal clearance ... See more keywords
Validation of the Augmented Renal Clearance in Trauma Intensive Care scoring system for augmented renal clearance prediction in a trauma subgroup of a mixed ICU population
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13695
Abstract: Augmented renal clearance is prevalent in trauma patients and leads to subtherapeutic levels of renally eliminated medications with potentially unfavourable clinical outcomes. The Augmented Renal Clearance of Trauma in Intensive Care (ARCTIC) score has been… read more here.
Keywords: augmented renal; intensive care; trauma; renal clearance ... See more keywords
Plasma trough concentration distribution and safety of high‐dose teicoplanin for patients with augmented renal clearance
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13700
Abstract: There are few reports on the distribution of the plasma trough concentration (Cmin) of teicoplanin in patients with augmented renal clearance (ARC) and on the safety of a high‐dose regimen (HD; 800 mg loading dose for… read more here.
Keywords: plasma trough; patients augmented; teicoplanin patients; renal clearance ... See more keywords
27 Risk factors of augmented renal clearance in critically ill children using iohexol clearance for renal function assessment
Sign Up to like & getrecommendations! Published in 2023 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2023-esdppp.27
Abstract: Introduction Augmented renal clearance(ARC) of hydrophilic drugs is frequent in PICU patients and warrants adjustment of standard dosing regimens to prevent therapeutic failure. Knowledge of patient-, disease- and therapy-related factors associated with ARC, would allow… read more here.
Keywords: clearance; critically ill; ill children; using iohexol ... See more keywords
Are Antibiotics Appropriately Dosed in Critically Ill Patients with Augmented Renal Clearance? A Narrative Review
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Clinical Practice"
DOI: 10.1155/2022/1867674
Abstract: Aims Augmented renal clearance (ARC), which is commonly defined as increased renal clearance above 130 ml/min/1.73 m2, is a common phenomenon among critically ill patients. The increased elimination rate of drugs through the kidneys in patients with… read more here.
Keywords: ill patients; critically ill; review; renal clearance ... See more keywords
Population Pharmacokinetics Modeling of Vancomycin Among Chinese Infants With Normal and Augmented Renal Function
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2021.713588
Abstract: There have been good amounts of population pharmacokinetics (PPK) models of vancomycin for Chinese pediatric patients, but none of them had a special focus on modeling infant population with different levels of renal function. Since… read more here.
Keywords: model; population pharmacokinetics; function; renal function ... See more keywords