Augmenter of liver regeneration knockout aggravates tubular ferroptosis and macrophage activation by regulating carnitine palmitoyltransferase‐1A‐induced lipid metabolism in diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2024 at "Acta Physiologica"
DOI: 10.1111/apha.14159
Abstract: Ferroptosis is a novel type of programmed cell death that performs a critical function in diabetic nephropathy (DN). Augmenter of liver regeneration (ALR) exists in the inner membrane of mitochondria, and inhibits inflammation, apoptosis, and… read more here.
Keywords: macrophage activation; ferroptosis; diabetic nephropathy; augmenter liver ... See more keywords
Augmenter of liver regeneration: A key protein in liver regeneration and pathophysiology
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology Research"
DOI: 10.1111/hepr.13077
Abstract: Liver is constantly exposed to pathogens, viruses, chemicals, and toxins, and several of them cause injury, leading to the loss of liver mass and sometimes resulting in cirrhosis and cancer. Under physiological conditions, liver can… read more here.
Keywords: regeneration key; liver regeneration; augmenter liver; liver ... See more keywords
Augmenter of liver regeneration enhances cell proliferation through the microRNA‐26a/Akt/cyclin D1 pathway in hepatic cells
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology Research"
DOI: 10.1111/hepr.13404
Abstract: Hepatocytes can proliferate and regenerate when injured by toxins, viral infections, and so on. Augmenter of liver regeneration (ALR) is a key regulator of liver regeneration, but the mechanism is unknown. The role of ALR… read more here.
Keywords: augmenter liver; enhances cell; cell proliferation; liver regeneration ... See more keywords
Augmenter of Liver Regeneration Alleviates Renal Hypoxia-Reoxygenation Injury by Regulating Mitochondrial Dynamics in Renal Tubular Epithelial Cells
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DOI: 10.14348/molcells.2019.0060
Abstract: Mitochondria are highly dynamic organelles that constantly undergo fission and fusion processes that closely related to their function. Disruption of mitochondrial dynamics has been demonstrated in acute kidney injury (AKI), which could eventually result in… read more here.
Keywords: augmenter liver; liver regeneration; alleviates renal; renal tubular ... See more keywords
Augmenter of liver regeneration protects against carbon tetrachloride-induced liver injury by promoting autophagy in mice
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DOI: 10.18632/oncotarget.14478
Abstract: Background Augmenter of liver regeneration (ALR) exerts strong hepatoprotective properties in various animal models of liver injury, but its protective mechanisms have not yet been explored. Autophagy is a recently recognized rudimentary cellular response to… read more here.
Keywords: augmenter liver; alr; liver regeneration; acute liver ... See more keywords
Augmenter of Liver Regeneration Protects Renal Tubular Epithelial Cells From Ischemia-Reperfusion Injury by Promoting PINK1/Parkin-Mediated Mitophagy
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.00178
Abstract: Ischemia–reperfusion (I/R) is the most common cause of acute kidney injury (AKI) and can induce apoptosis in renal epithelial tubule cells. Mitochondrial dysfunction is one of the main reasons for I/R-induced apoptosis. Accumulating evidence suggests… read more here.
Keywords: mediated mitophagy; augmenter liver; parkin; ischemia reperfusion ... See more keywords