Augmenting ATG14 alleviates atherosclerosis and inhibits inflammation via promotion of autophagosome-lysosome fusion in macrophages.
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DOI: 10.1080/15548627.2021.1909833
Abstract: Dysfunction of macroautophagy/autophagy in macrophages contributes to atherosclerosis. Impaired autophagy-lysosomal degradation system leads to lipid accumulation, facilitating atherosclerotic plaque. ATG14 is an essential regulator for the fusion of autophagosomes with lysosomes. Whether ATG14 plays a… read more here.
Keywords: lysosome fusion; inflammation; autophagosome lysosome; augmenting atg14 ... See more keywords