Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug.
Sign Up to like & getrecommendations! Published in 2019 at "Biochimie"
DOI: 10.1016/j.biochi.2019.03.015
Abstract: Auranofin is a gold (I)-containing compound used for the treatment of rheumatic arthritis. Auranofin has anticancer activity in animal models and is approved for clinical trials for lung and ovarian carcinomas. Both the cytosolic and… read more here.
Keywords: thioredoxin reductase; inhibitor; proteasome; activity ... See more keywords
Auranofin promotes antibacterial effect of doripenem against carbapenem‐resistant Acinetobacter baumannii
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Microbiology"
DOI: 10.1111/jam.15644
Abstract: This study was performed to identify the potential for repurposing auranofin as an antibiotic adjuvant against carbapenemase‐producing Acinetobacter baumannii. read more here.
Keywords: auranofin promotes; antibacterial effect; auranofin; effect doripenem ... See more keywords
Auranofin attenuates hepatic steatosis and fibrosis in nonalcoholic fatty liver disease via NRF2 and NF-κB signaling pathways
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Molecular Hepatology"
DOI: 10.3350/cmh.2022.0068
Abstract: Background/Aims We aim to evaluate the effects of auranofin, a known antioxidant, on hepatic steatosis, inflammation, and fibrosis, contributing to non-alcoholic steatohepatitis (NASH) development in vivo and in vitro. Methods Transcriptome analysis of LX-2 cells… read more here.
Keywords: auranofin; expression; hepatic steatosis; auranofin attenuates ... See more keywords
Auranofin Resistance in Toxoplasma gondii Decreases the Accumulation of Reactive Oxygen Species but Does Not Target Parasite Thioredoxin Reductase
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.618994
Abstract: Auranofin, a reprofiled FDA-approved drug originally designed to treat rheumatoid arthritis, has emerged as a promising anti-parasitic drug. It induces the accumulation of reactive oxygen species (ROS) in parasites, including Toxoplasma gondii. We generated auranofin… read more here.
Keywords: reactive oxygen; reductase; accumulation reactive; gondii ... See more keywords
Synergistic Microbicidal Effect of Auranofin and Antibiotics Against Planktonic and Biofilm-Encased S. aureus and E. faecalis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.02453
Abstract: Methicillin-resistant/susceptible Staphylococcus aureus (MRSA/MSSA) and Enterococcus faecalis strains are often found in community- and hospital-acquired infections. The single use of conventional antibiotics hardly completely kills the bacterial cells of interest, especially in the form of… read more here.
Keywords: combination; microbicidal effect; effect; synergistic microbicidal ... See more keywords
Auranofin Attenuates Non-Alcoholic Fatty Liver Disease by Suppressing Lipid Accumulation and NLRP3 Inflammasome-Mediated Hepatic Inflammation In Vivo and In Vitro
Sign Up to like & getrecommendations! Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9111040
Abstract: Non-alcoholic fatty liver disease (NAFLD) causes liver dysfunction and is associated with obesity and type 2 diabetes. Chronic inflammation is associated not only with the development of NAFLD, but also with hepatic diseases, including steatohepatitis,… read more here.
Keywords: non alcoholic; treatment; inflammation; nlrp3 inflammasome ... See more keywords
Anti-Staphylococcal Activity of the Auranofin Analogue Bearing Acetylcysteine in Place of the Thiosugar: An Experimental and Theoretical Investigation
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27082578
Abstract: Auranofin (AF, hereafter) is an orally administered chrysotherapeutic agent approved for the treatment of rheumatoid arthritis that is being repurposed for various indications including bacterial infections. Its likely mode of action involves the impairment of… read more here.
Keywords: staphylococcal activity; auranofin; anti staphylococcal; analogue bearing ... See more keywords
Anti-Cancer Effects of Auranofin in Human Lung Cancer Cells by Increasing Intracellular ROS Levels and Depleting GSH Levels
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27165207
Abstract: Auranofin, as a thioredoxin reductase (TrxR) inhibitor, has promising anti-cancer activity in several cancer types. However, little is known about the inhibitory effect of auranofin on lung cancer cell growth. We, therefore, investigated the antigrowth… read more here.
Keywords: lung cancer; ros levels; auranofin; cancer ... See more keywords