Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex
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DOI: 10.1371/journal.pone.0266143
Abstract: Disrupting the formation of the oncogenic YAP/TAZ-TEAD transcriptional complex holds substantial therapeutic potential. However, the three protein interaction interfaces of this complex cannot be easily disrupted using small molecules. Here, we report that the pharmacologically… read more here.
Keywords: taz; aurintricarboxylic acid; taz tead; transcriptional complex ... See more keywords
Characterization of Aurintricarboxylic Acid (ATA) Interactions with Plasma Transporter Protein and SARS-CoV-2 Viral Targets: Correlation of Functional Activity and Binding Energetics
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12060872
Abstract: In an effort to identify functional-energetic correlations leading to the development of efficient anti-SARS-CoV-2 therapeutic agents, we have designed synthetic analogs of aurintricarboxylic acid (ATA), a heterogeneous polymeric mixture of structurally related linear homologs known… read more here.
Keywords: aurintricarboxylic acid; plasma transporter; activity; acid ata ... See more keywords